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Directed evolution, enzyme

Directed Enzyme Evolution Screening and Selection Methods, Humana Press, Totowa. Vol. 230. (b) Brakmann, S. and Johnsson, K. (eds)(2002) Directed Molecular Evolution of Proteins (or How to Improve Enzymes for Biocatalysis), Wdey-VCH Verlag GmbH, Weinheim. (c) Brakmann, S. and Schwienhorst, A. (eds)... [Pg.57]

Directed Enzyme Evolution and High-Throughput Screening... [Pg.9]

Arnold, F.H. and Georgiou, G. (eds) (2003) Directed Enzyme Evolution Screening and Selection Methods, Methods in Molecular Biology, vol. 230, Humana Press, Inc., Clifton, NJ. [Pg.31]

Farinas, E.T., Bulter, T., Arnold, F.H., Directed enzyme evolution, Curr. Opin. Biotech-nol. 2001, 22, 545-551... [Pg.512]

Gupta, R.D. and Tawfik, D.S., Directed enzyme evolution via small and effective neutral drift libraries. Nat. Methods, 2008, 5, 939-942. [Pg.115]

Screening of Large Libraries and Directed Enzyme Evolution... [Pg.211]

Tao, H. and V.W. Cornish 2002. Milestones in directed enzyme evolution. Curr. Opin. Chem. Biol. 6 858-864. [Pg.31]

Directed enzyme evolution using the selection of phage-clisplayed enzymes is a powerful tool that represents an attractive alternative to the popular high-throughput screening technologies. [Pg.64]

G. Georgiou, Directed Enzyme Evolution (Screening and Selection Methods), Humana Press, Totowa, New Jersey, 2003. [Pg.140]

Fig. 1. A working strategy for directed enzyme evolution. The screening method should ensure that small enhancements brought about mainly by single mutations can be measured. The evolution of a new, useful enzyme requires an effective strategy for accumulating many such small improvements. Beneficial mutations can be accumulated in a sequential generations of random mutagenesis and screening or b by (random) recombination... Fig. 1. A working strategy for directed enzyme evolution. The screening method should ensure that small enhancements brought about mainly by single mutations can be measured. The evolution of a new, useful enzyme requires an effective strategy for accumulating many such small improvements. Beneficial mutations can be accumulated in a sequential generations of random mutagenesis and screening or b by (random) recombination...
Altamirano, M. M., Blackburn, J. M., Aguayo, C., and Fersht, A. R. (2000). Directed evolution of new catalytic activity using the a//3-barrel scaffold. Nature 403, 617-622. Arnold, F. H. (1998). Design by directed evolution. Acct. Chem. Research 31, 125-131. Arnold, F. H. (2000). Directed enzyme evolution, http //www.che.caltech.edu/groups/ fha/Enzyme/directed.html... [Pg.311]

Figure 4 Schematic representation of a phage display-based selection method for directed enzyme evolution E enzyme, S substrate P product. Figure 4 Schematic representation of a phage display-based selection method for directed enzyme evolution E enzyme, S substrate P product.
Arnold FH, Georgiou G. Directed Enzyme Evolution Screening and Selection Mefliods. 2003. Humana Press, Totowa, NJ. [Pg.344]

Rubin-Pitel SB, Zhao H. Recent advances in biocatalysis by directed enzyme evolution. Comb. Chem. High Throughput Screen 2006 9 247-257. [Pg.344]

Fig. 10.15. Key steps of a typical directed enzyme evolution experiment. Fig. 10.15. Key steps of a typical directed enzyme evolution experiment.
Jestin, J.L. Kaminski, P.A. Directed enzyme evolution and selections for catalysis based on... [Pg.2200]

Arnold EH, Georgiou G (2003) Directed enzyme evolution screening and selection methods. Humana, Totowa, NJ... [Pg.89]

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See also in sourсe #XX -- [ Pg.180 ]



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