Buccal cavity bioadhesion

Buccal, sublingual, oral cavity Buccal mucosa gingival sulcus Bioadhesive patch biodegradable solution matrix, tablet... 

The term mucoadhesion is commonly used to describe an interaction between the mucin layer, which lines the entire GI tract, and a bioadhesive polymer, which could be natural or synthetic in origin.From the oral delivery standpoint, these systems are used to immobilize and localize a drug delivery device in the selected regions of the GI tract, which could be an oral cavity (buccal and sublingual routes), the esophagus, stomach, small intestine, or colon (oral route). For the most part, research in this area has focused on the design of polymeric micro- and nanoparticulate systems that use hydrophilic polymers, primarily due to their propensity to interact with the mucosal surface. ... 

An ideal buccal deUveiy system should stay in the oral cavity for at least few hours and release the active ingredients in a unidirectional way towards the mucosa in a controlled or sustained-release fashion. Muco- and bioadhesive polymers are supposed to prolong the residence time of the device in the oral cavity. One of the experiments developed a direct staining method to visualize the polymer adhesion to human buccal cells after exposure to an aqueous dispersion of chitosan. An in vivo study was performed on a test group of human subjects, who rinsed with... 

---