Bioactive compounds antimicrobial activity

Pantothenate kinase phosphorylates Vitamin B6, the first and rate controlling step in Coenzyme A biosynthesis. Due to the lack of pantothenate kinase inhibitors and activators, the exact physiological role of this enzyme in metabolism and disease is not yet known. In a recent study aimed at the discovery of antimicrobial agents, a set of novel inhibitors of S. aureus pantothenate kinase were disclosed that also inhibited mammalian (murine) pantothenate kinase with high micromolar IC50 values.235 A team at St. Jude Children s Hospital studied a library of known bioactive compounds to find inhibitors of pantothenate kinase. Several inhibitors with IC50 values below 10 pM were identified.236... 

In the early days of natural products research, new compounds were simply isolated at random, or at best by the use of simple broad-based bioactivity screens based on antimicrobial or cytotoxicity activities. Although these screens did result in the isolation of bioactive compounds, including many of those described earlier, they have been... 

Modified polysaccharide biopolymers have found applications from permselective membranes to ionically conductive membranes for fuel cells. In this review, ionically selective membranes in particular will be explored. Recent studies and advances in using modified polysaccharides for food applications will also be reviewed with specific attention given to their potential uses in the development of active food packaging solutions, which include antimicrobial systems, coatings and bioactive compound delivery systems. 

Abstract Recent chemical studies on the marine soft corals and terrestrial plants have resulted in the isolation of several novel compounds. The soft corals, Pseudopterogorgia elisabethae and Cladiella species yielded several novel terpenoids, exhibiting antimicrobial activities. New steroids were isolated from terrestrial fungi, Mucor plumbeus and Coprims micaceus. Phytochemical studies on the Bwcus hyrcana, collected from Iran, have yielded steroidal bases. This review describes the new natural products exhibiting different bioactivities from the aforementioned sources. 

All parts of J. curcas L. is used in medical and veterinary purposes. The seeds, leaves, and bark contain toxins and phytochemicals, which have moUuscidal and insecticidal properties (Rug et al. 1997 Rahuman et al. 2008). Various phytochemicals of J. curcas L. were identified and studied for their antitumor (Balaji et al. 2009), anti-inflammatory (Mujumdar and Misar 2004), antimicrobial (Ravindranath et al. 2004), antiviral (Matsuse et al. 1998), and wound healing activity (Nath and Dutta 1992 Esimone et al. 2008). The bioactive compounds are not only used in medical and veterinary but could also be used in agriculture. 

The aminophosphonates formed from aromatic amines have the highest bioactivity. Bioactivity tests carried out with this family of compounds indicate that the increase in the number of carbon atoms of the alkyl group leads to reduction of the preparations efficiency. The degree of branching of the residue does not influence the biological activity of these compounds. The introduction of the ferrocene fragment in the above molecule, on the other hand, leads to a substantial increase of the antimicrobial activity. 

---