Bioabsorbable stent

Future Directions in Stent Engineering Bioabsorbable Stents 56 References 57... 

Keywords Coronary stent Bare metal stent Drug-eluting stent Restenosis Late thrombosis Bioabsorbable stent Future generation stent... 

Fig. 5 (A) The expanded Igaki-Tamai bioabsorbable stent showing the zigzag helical coil with straight bridges, (B) the BVS stent with the two different designs, (C) the REVA stent in its expanded form, (D) the bioabsorbable salicylic acid-based stent, and (E) a bioabsorbable magnesinm stent unexpanded on the left and expanded on the right with different magnifications [88].

A method of fabricating a bioabsorbable stent has been described that consists of (66) ... 

Bioabsorbable polymeric stents can trigger acute or chronic inflammatory responses due to the degradation of the stent. The vascular response to a fully bioabsorbable stent can be more different than that of a metal- or polymer-coated stent. Polymers are listed in Table 7.5. Anti-inflammatory drugs are listed in Table 7.6. 

W.J. Fox, N. Harold, A. Garcia, and A. Tochterman, Bioabsorbable stent with prohealing layer, US Patent 8 535372, assigned to Abbott Cardiovascular Systems Inc. (Santa Clara, CA), September 17, 2013. 

Waksman, R. (2006). Update on bioabsorbable stents from bench to clinical,/ Interv. Cardiol, 19,414-421. 

Ormiston J, Serruys PW, Regar E, et al. A bioabsorb-able everolimus-eluting coronary stent system for patients with single de-novo coronary artery lesions (ABSORB) a prospective open-label trial. Lancet 2008 371 899-907. 

Grube E, Sonoda S, Ikeno E et al. Six- and twelve-month results from first human experience using everolimus-eluting stents with bioabsorbable polymer. Circulation 2004 ... 

The Future of Polymer Based Bioabsorbable Drug Eluting Stents http //www.tctmd.com/csportal/appmanagerActmd/ main nfpb=true pageLabel=TCTMDContent hd Con = 1270085. 

FUTURE DIRECTIONS IN STENT ENGINEERING BIOABSORB ABLE STENTS... 

Erbel R, Di Mario C, Bartunek J, et al. Temporary scaffolding of coronary arteries with bioabsorbable magnesium stents a prospective, non-randomised multicentre trial. Lancet 2007 369(9576) 869-75. 

J.A. Ormiston, M.W.I. Webster, G. Armstrong, First-in-human implantation of a fully bioabsorbable drug-eluting stent the BVS poly-L-lactic acid everolimus-eluting coronary stent. Catheter. Cardiovasc. Interv. 69 (2007) 128-131. 

J.A. Ormiston, P.W. Serruys, Bioabsorbable coronary stents, Circ. Cardiovasc. Interv. 2 (2009) 255-260. 

Finally, we have the Bioabsorbable therapeutics stent (Bioreabsorbable Therapeutics Inc., Menlo Park, CA), a sirolimus-eluting FBS composed of salicylic acid. It is also coated with a polymer layer responsible for controlled release of the drugs (Figure 5D). The coating is made up of repeated salicylic acid molecules... 

Serruys, P.W., et al. Absorb trial first-in-man evaluation of a bioabsorbable everolimus-eluting coronary stent system two-year outcomes and results from multiple imaging modalities. Lancet 373, 897-910 (2009)... 

In the treatment of vascular disease such as arteriosclerosis, intracoronary stent placement is a common adjimct to balloon angioplasty (74). Stents, however, can also cause imdesirable side effects. For example, the continued exposure of a stent to blood can lead to thrombus formation and the presence of a stent in a blood vessel can over time cause the blood vessel wall to weaken creating the potential for arterial rupture or formation of aneurisms. A stent can also become overgrown by tissue after its implantation such that its utility is diminished or eliminated while its continued presence may lead to a variety of complications such as the foregoing. To ameliorate the above situation, stents can be fabricated from materials that are biodegradable and, if desired, bioabsorbable (74). 

Also, it may be desirable for a stent to be biodegradable. In many treatment applications, the presence of a stent in a body may be necessary only for a limited period. Therefore, stents fabricated from biodegradable, bioabsorbable, or bioerodable materials should be configured to completely disappear after the clinical need for them has ended (66). 

Jabara, R., Chronos, N., Robinson, K., 2008. Novel bioabsorbable salicylate-based polymer as a drug-eluting stent coating. Catheterization and Cardiovascular Interventions 72, 186-194. 

J.P. Nuutinen, C. Clerc, R. Reinikainen, P. Tormala, Mechanical properties and in vitro degradation of bioabsorbable self-expanding braided stents. Biomater. Sd. Polym. Ed. 14 (3) (2003) 255-266. 

C. Di Mario, H. Griffiths, O. Goktekin, N. Peeters, J. Verbist, M. Bosiers, K. Deloose, B. Heublein, R. Rohde, V. Kasese, C. Ilsley, R. Erbel, Drug-eluting bioabsorbable magnesium stent. J. Interv. Cardiol. 17(6), 391-395 (2004)... 

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