Binding of drug

One of the plasma proteins which is mainly responsible for the plasma protein binding of drugs. Its level is known to be elevated in some pathological states, such as inflammation. 

Kratochwil NA, Huber W, Muller F, Kansy M and Gerber PR. Predicting plasma protein binding of drugs a new approach. Biochem Pharmacol 2002 64 1355-74. 

Eischer, H. Passive diffusion and active transport through biological membranes - binding of drugs to... 

These include absorption by adjacent palpebral and bulbar conjunctiva, with concomitant rapid removal from ocular-tissues by peripheral blood flow. For example, the extensive vascularity of the uvea underlies the bulbar conjunctiva, a mucous membrane, and the sclera, a white tissue providing a tough outer covering [177]. Binding of drug to either external sites, like the tear polymers such as mucins or lysozyme, or internal tissues like the sclera can be detrimental to efficacy. 

L. Notarianni, Plasma protein binding of drugs in pregnancy and in neonates, Clin. Pharmacokinet, 18, 20 (1990). 

Interaction with non-steroidal anti- Binding of drugs to albumin that increases... 

Herve F, Gomas E, Duche JC, Tille-ment JP. Evidence for differences in the binding of drugs to the two main genetic variants of human alpha 1-acid glycopro-... 

Of the following, which is unlikely to be associated with the binding of drugs to plasma proteins ... 

The binding of drugs to plasma proteins has a significant effect on pharmacokinetics and pharmacodynamics. The fraction of unbound drug, also called the... 

After binding of drug and receptor, a cascade of signal transductions occur within the cell and are manifested as a variety of effects on the diseased biochemical pathways. 

Binding of drug or drug-carrier conjugate to plasma proteins and various other non-target tissues [46,55], which potentially act as a slow release compartments (see Section 13.2.1.4). 

Plasma contains a large variety of proteins, all of which have the potential to interact with drugs. Albumin is generally considered to be the most important contributor to the plasma protein binding of drugs (GIO, Gil, M16), but for some, e.g., steroids, other proteins play a major role. 

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