Lipid-regulating agents

A woman with hypertriglyceridemia and breast cancer was given tamoxifen and various lipid-regulating agents after mastectomy. She stopped the latter of her own accord after 2 years and had a recurrence of hypertriglyceridemia and pancreatitis. 

Sheperd J. The statin era in search of the ideal lipid regulating agent. Heart, 2001, 85, 259-264. 

Oku, K., Kubota, M., Fukuda, S. Miyake, T. (2006b) Lipid regulating agent and use thereof. United States Patent Application US 2006/0276432 A1,7 December 2006. 

Lipid-regulating agents (3-Blockers and (32-sympathomimetics Anticancer/Antrneop lastic/ Psychiatric drugs... 

GC-MS has often been used to analyze acidic lipid-regulating agents (e.g., gemfibrozil, benzafibrate, and clofibric acid, a metabolite) after derivatization together with acidic NSAlDs, while neutral "fibrate" compounds (e.g., etofibrate, fenofibrate, and clofibrate) were analyzed directly without derivatization (Table 25.7) [82-84,92,129,132,137,138]. 

LC-ESI-MS/MS has been used to determine lipid-regulating agents, including the fibrates and statins classes in water. For the fibrates, N1 mode was generally employed with deprotonated molecules [M — H] at m/z 213 for clofibric acid, m/z 249 for gemfibrozil, and m/z 360 for bezafibrate [85,87,140,147]. However, PI mode was also used for fenofibrate and bezafibrate [86]. In ESI(—) tandem MS mode, the deprotonated molecule of clofibric... 

List of MRM Transitions for the LC-MS/MS Analysis of Antiinflammatory, Analgesics, Antiphlogistics, and Lipid-Regulating Agents... 

Maximal respiratory depression occur more rapidly with more lipid-soluble agents. After therapeutic doses, respiratory minute volume may be reduced for as long as 4-5 hours. The respiratory depression by opioids involves a reduction in the responsiveness of the brainstem respiratory centers to COj. Opioids also depress the pontine and medullary centers involved in regulating respiratory rhythmicity. 

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