Berkeley Madonna

Berkeley Madonna University of California-Berkeley http //www.berkeleymadonna.com/... 

BERKELEY MADONNA PC and Mac Easy to use, powerful, highly interactive, easy and effective parameter estimation and optimisation. 

For the software of particular interest here, refer to the following websites BERKELEY MADONNA, www.berkeleymadonna.com MODELMAKER, www. modelkinetix.com/modelmaker/ MATLAB, http //www.mathworks.com ACSL, http //www.aegisxcellon.com/ HYSYS and SPEEDUP http //www.aspentec.com... 

The Screenshot Guide in the Appendix provides a full explanation for the major features of BERKELEY-MADONNA and the mechanics of running the simulation examples. The Help menu of MADONNA should also be consulted. 

The excellent software BERKELEY-MADONNA enables a more modern, Windows-based (also Macintosh compatible) and menu driven solution. 

We are very grateful to all our past post-experience course participants and university students who have helped us to develop and improve some of the examples. In addition, we would like to thank Tim Zahnley, one of the developers of BERKELEY-MADONNA, for his help with software questions. Members of Wiley-VCH helped us in the editing and printing of this third edition, and for this we are grateful. 

Many early PBPK modeling efforts were based on the Simusolv software, and support for this seems not readily available at the present time. More recently the ACSL and Berkeley Madonna (University of California, Berkley, CA) have become more widely used. In addition to these computer software packages, Haddad et al. [35] demonstrated the application of a spreadsheet program to support a PBPK model, and Trent University (Peterborough, Ontario, Canada, updated 2003) made available a spreadsheet program to run PBPK models. Further there are several computer-assisted applications, several as freeware, to perform pharmacokinetic analyses and interpret in vitro enzyme kinetic data (see Chapter 3). 

In this chapter the simulation examples are presented. They are preceded by a short describtion of simulation tools and the Berkeley Madonna program in particular. As seen from the Table of Contents, the examples are organised according to twelve application areas Batch Reactors, Continuous Tank Reactors, Tubular Reactors, Semi-Continuous Reactors, Mixing Models, Tank Flow Examples, Process Control, Mass Transfer Processes, Distillation Processes, Heat Transfer, Diffusion Transfer and Biological Process Examples. There are aspects of some examples that make them relevant to more than one application area, and this is usually apparent from their titles. Within each section, the examples are listed in order of their degree of difficulty. 

Berkeley Madonna, University of California at Berkeley, http //www.berkeleymadonna.com/ ModelMaker, Cherwell Scientific Publishing Ltd., The Magdalen Centre, Oxford Science Park, Oxford 0X4 4GA, http //www.cherwell.com/. UK Matlab, The MathWorks, Inc., 24 Prime Park Way, Natick, MA 01760, http //www.mathworks.com. USA ACSL-Optimize, Aegis Research Corporation, 6703 Odyssey Drive, Suite 200, Huntsville, Alabama 35806, http //www.aegisrc.com/. USA SPEEDUP, Aspen Technology, Inc. Ten Canal Park, Cambridge, Mass. 02141. http //www.aspentec.com. USA. 

The Screenshot Guide in the Appendix provides further explanations for these and other features of Berkeley Madonna. 

Finally, we are grateful to the developers of Berkeley Madonna for permission to include their software on our CD-ROM. 

Berkeley Madonna (commercial) WWW.berkeleymadonna.com General purpose differential equation solver... 

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