Software Berkeley Madonna

The excellent software BERKELEY-MADONNA enables a more modern, Windows-based (also Macintosh compatible) and menu driven solution. 

GENERAL-PURPOSE HIGH-LEVEL SCIENTIFIC COMPUTING SOFTWARE Berkeley Madonna, University of California at Berkeley, http / / www.berkeleymadonna.com... 

For the software of particular interest here, refer to the following websites BERKELEY MADONNA, www.berkeleymadonna.com MODELMAKER, www. modelkinetix.com/modelmaker/ MATLAB, http //www.mathworks.com ACSL, http //www.aegisxcellon.com/ HYSYS and SPEEDUP http //www.aspentec.com... 

We are very grateful to all our past post-experience course participants and university students who have helped us to develop and improve some of the examples. In addition, we would like to thank Tim Zahnley, one of the developers of BERKELEY-MADONNA, for his help with software questions. Members of Wiley-VCH helped us in the editing and printing of this third edition, and for this we are grateful. 

Many early PBPK modeling efforts were based on the Simusolv software, and support for this seems not readily available at the present time. More recently the ACSL and Berkeley Madonna (University of California, Berkley, CA) have become more widely used. In addition to these computer software packages, Haddad et al. [35] demonstrated the application of a spreadsheet program to support a PBPK model, and Trent University (Peterborough, Ontario, Canada, updated 2003) made available a spreadsheet program to run PBPK models. Further there are several computer-assisted applications, several as freeware, to perform pharmacokinetic analyses and interpret in vitro enzyme kinetic data (see Chapter 3). 

Finally, we are grateful to the developers of Berkeley Madonna for permission to include their software on our CD-ROM. 

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