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Benzodiazepines muscle spasms

Diazepam (Valium, Diastat) [C-IVj [Anxiolytic, Skeletal Muscle Relaxant, Anticonvulsant, Sedative/Hypnotic/ Benzodiazepine] Uses Anxiety, EtOH withdrawal, muscle spasm, status epilepticus, panic disorders, amnesia, preprocedure sedation Action Benzodiazepine Dose Adults. Status epilepticus 5-10 mg IV/IM Anxiety 2-5 mg IM/IV Preprocedure 5-10 mg IV just prior to procedure Peds. Status epilepticus 0.5-2 mg IV/IM Sedation 0.2-0.5 mg/kg IV (onset w/in 5IV and 30 min IM duration about 1 h IV and IM) Caution [D, / -] Contra Coma, CNS depression, resp d es-sion, NAG, severe uncontrolled pain, PRG Disp Tabs 2, 5, 10 mg soln 1, 5 mg/mL inj 5 mg/mL rectal gel 2.5, 5, 10, 20 mg/mL SE Sedation, amnesia, bradycardia, i BP, rash, X resp rate Interactions T Effects W/ antihistamines, azole antifungals, BBs, CNS depressants, cimetidine, ciprofloxin, disulfiram, INH, OCP, omeprazole, phenytoin, valproic acid, verapamil, EtOH, kava kava, valman T effects OF digoxin, diuretics X effects w/ barbiturates, carbamazepine. [Pg.13]

The benzodiazepines bind to a specific GABA receptor site to affect mood, spasticity, seizures and sleep. The benzodiazepines are reported to be effective in certain chronic pain syndromes characterized by muscle spasm, concomitant chronic pain and anxiety. [Pg.440]

Benzodiazepines have the capacity to depress polysynaptic reflexes and have been shown to decrease decerebrate rigidity in cats and spasticity in patients with cerebral palsy. What is not clear is whether they can, in humans, relax voluntary muscles in doses that do not cause considerable central nervous system depression. Nevertheless, benzodiazepines, such as diazepam, are often prescribed for patients who have muscle spasms and pain as a result of injury. In these circumstances, the sedative and anxiolytic properties of the drug also may promote relaxation and relieve tension associated with the condition. [Pg.359]

Some sedative-hypnotics, particularly members of the carbamate (eg, meprobamate) and benzodiazepine groups, exert inhibitory effects on polysynaptic reflexes and internuncial transmission and at high doses may also depress transmission at the skeletal neuromuscular junction. Somewhat selective actions of this type that lead to muscle relaxation can be readily demonstrated in animals and have led to claims of usefulness for relaxing contracted voluntary muscle in muscle spasm (see Clinical Pharmacology). Muscle relaxation is not a characteristic action of zolpidem, zaleplon, and eszopiclone. [Pg.480]

The depressant effect of barbiturates is often sought by persons who are self-medicating for amdety-related problems or insomnia. Drugs of the benzodiazepine family (Librium, Valium, and Xanax) are also legitimately prescribed for the treatment of anxiety as well as muscle spasms or convulsions. However, doctors and patients must be careful because prolonged or excessive use can lead to dependence. Illegal use often involves forged prescriptions or the cooperation of illicit doctors. [Pg.12]

Benzodiazepine psychoactive drugs that are used for anxiety, insomnia, muscle spasms and seizures. [Pg.321]

Remains a popular benzodiazepine for treating muscle spasms... [Pg.113]

Uses. Benzodiazepines are used for insomnia, anxiety, alcohol withdrawal states, muscle spasm due to a variety of causes, including tetanus and cerebral spasticity, epilepsy (clonazepam, see p. 421), anaesthesia and sedation for endoscopies and cardioversion. [Pg.400]

Benzodiazepines also are used for purposes other than anxiety and insomnia management. For example, benzodiazepines have muscle-relaxant and anticonvulsant actions and arc often used as a treatment for muscle spasms and seizures. Short-acting benzodiazepines such as midazolam (trade name Versed) arc used as anesthetics in some surgical procedures. [Pg.341]

The CNS contains a wide variety of neurotransmitters and high concentrations of receptors. Mechanisms of action of many drugs are often complex combinations of receptor-based actions. Some of the most widely used (and abused) drugs are hypnotics/sedatives, for treatment of insonmia. Barbiturates such as amylo-barbitone have been used for many years, but suffer from side-effects and are addictive. Thiopentone sodium salt (sodium pentothal), however, is very useful as a short-acting intravenous anaesthetic. The benzodiazepines, such as diazepam (Valium) and alprazolam (Xanax), are safer drags for insomnia and also can be used for treatment of anxiety and muscle spasms. Zolpidem (Ambien) is a newer and more selective hypnotic. [Pg.658]

Diazepam (Valium), a benzodiazepine, to a client with muscle spasms. [Pg.204]

Benzodiazepines are also being used in the symptomatic treatment of dystonias with prominent muscle spasms. [Pg.366]

Benzodiazepines also possess muscle relaxant activity. Their pharmacology is discussed in Chapter 30. Diazepam Valium) has been used for control of flexor and extensor spasms, spinal spasticity, and multiple sclerosis. The muscle relaxant effect of the benzodiazepines may be mediated by an action on the primary afferents in the spinal cord, resulting in an increased level of presynaptic inhibition of muscle tone. Polysynaptic reflexes are inhibited. The most troublesome side effect is drowsiness, which is dose dependent. Tolerance to both the therapeutic effects and the side effects develops. [Pg.344]

Spasmolytics reduce excess muscle tone or spasm in injury or CNS dysfunction. They may act in the CNS, the spinal cord, or directly on the muscle. Benzodiazepines and baclofen reduce the tonic output of spinal motor neurons. Dantrolene blocks Ca2 release from the muscle sarcoplasm reticulum. [Pg.174]


See other pages where Benzodiazepines muscle spasms is mentioned: [Pg.402]    [Pg.307]    [Pg.211]    [Pg.131]    [Pg.347]    [Pg.73]    [Pg.592]    [Pg.131]    [Pg.628]    [Pg.211]    [Pg.182]    [Pg.2468]    [Pg.97]    [Pg.100]    [Pg.348]    [Pg.125]    [Pg.131]    [Pg.204]    [Pg.383]    [Pg.435]    [Pg.365]    [Pg.247]    [Pg.31]   
See also in sourсe #XX -- [ Pg.164 , Pg.165 ]




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