Benzene, l-bromo-4-methoxy

Benzene, l-bromo-4-fluoio-, 55, 51 Benzene, l-bromo-4-methoxy-, 55, 51 Benzene l-bromo-3-methyl-, 55, 51 Benzene, 4-fezf-butyl-l-ethyl- [Benzene, 4-(l,l-dimethylethyl)-1-ethyl-], 55,... 

Benzenamine [62-53-3], 122 Benzenamine, 2-methyl- [95-53-4], 86 Benzene, (2-bromoethyl)- [103-63-9], 82 Benzene, (bromomethyl)- [100-39-0], 78 Benzene, l-bromo-4-methyl- [106-38-7], 86 Benzene, chloro- [108-90-7], 86 Benzene, l-chloro-4-methyl- [106-43-4], 86 Benzene, l-(chloromethyl)4-methoxy-[824-94-2], 82... 

Benzaldehyde, 4-ethoxy-3-methoxy-, 56, 44 Benzaldehyde, 4-ethoxy-3-methoxy-, ethylene acetal, 56, 44 Benzaldehyde, 4-isopropyl-, 55,10 Benz[e ] anthracene, 58, 15, 16 BENZENAMINE, 4-bromo-Ar, V-dimcthyl-3-(tnfluoromethyl)-, 55, 20 Benzene, bromo-, 55,51 Benzene, 1 bromo-4-chloro-,55, 51 Benzene, 4-bromo-l, 2-dimethyl, 55, 51 Benzene, l-bromo-4-fluoro-, 55, 51 Benzene, 1 -bromo-4-methoxy-, 55,51 Benzene, l-bromo-3-methyl-, 55, 51 Benzene, 4-(cr/-buty 1-1-ethyl, 55, 10 Benzene, chemical hazard warning, 58, 168 Benzene, chloro-,56, 86 Benzene, l-ethyl-4-isopropyl-, 55, 10... 

In addition, this coupling system resulted in an efficient coupling between 2-stannyl-thiophene and l-bromo-4-methoxy-6-methyl-benzene (204) at 50°C to afford 205 in excellent yield. 

Ethanone, 1- [3-(l,l-dimethylethyl)-4-methoxy-5-nitrophenyl Benzaldehyde, 2 (l,l-dimethylethyl)-4-methoxy-5-nitro Benzene, 1,4-BIS- (1, l-dimethylethyl)-2 methoxy-5-nitro Benzene, 1-(1, l-dimethylethyl)-2, 5-dimethoxy-4-nitro Benzene, 1-(1, l-dimethylethyl)-2-methoxy-4 methyl-5-nitro Benzaldehyde, 5- (1, l-dimethylethyl)-2-methyl-3-nitro Benzaldehyde, 2- (1, l-dimethylethyl)-4,5,6-trimethyl-3-nitro Benzene, 5-(l, l-dimethylethyl)-2-methoxy-l, 3-dinitro Benzene, 1-(1, l-dimethylethyl)-4-methoxy-2-methyl 3-5-dinitro Benzene, 2-bromo-5- (1, l-dimethylethyl)-4-methoxy-l,... 

MMUS Benzene, l-bromo-6-(l,l-dimethylethyl)-3-methoxy-2,4-dinitro-... 

Condensation of l-bromo-2-methoxy-4-methyl benzene (64) with 5,6-dimethoxyaniline acetate (65) in pyridine in the presence of Cu and K2CO3 and subsequent hydrolysis with 20% KOH furnished the di-phenylamine derivative (66) which on treatment with palladium acetate in DMF afforded murrayastine (13). Condensation of l-bromo-3-methoxy-4-methylbenzene (67) with the dimethyl acetal of 6-formyl-5-methoxyaniline acetate (68) furnished the diphenylamine derivative (69) which on hydrolysis and on subsequent cyclisation furnished murray-aline (14). 

A kinetic isotope effect, kH/kD = 1.4, has been observed in the bromination of 3-bromo-l,2,4,5-tetramethylbenzene and its 6-deuterated isomer by bromine in nitromethane at 30 °C, and this has been attributed to steric hindrance to the electrophile causing kLx to become significant relative to k 2 (see p. 8)268. A more extensive subsequent investigation304 of the isotope effects obtained for reaction in acetic acid and in nitromethane (in parentheses) revealed the following values mesitylene, 1.1 pentamethylbenzene 1.2 3-methoxy-1,2,4,5-tetramethyl-benzene 1.5 5-t-butyl-1,2,3-trimethylbenzene 1.6 (2.7) 3-bromo-1,2,4,5-tetra-methylbenzene 1.4 and for 1,3,5-tri-f-butylbenzene in acetic acid-dioxan, with silver ion catalyst, kH/kD = 3.6. All of these isotope effects are obtained with hindered compounds, and the larger the steric hindrance, the greater the isotope... 

The reaction of 1-alkoxynaphtalenes with copper (II) bromide in benzene produced a mixture of 4-bromo-1-alkoxynaphtalenes and 4,4 -dialkoxy-l,l -binaphtyls. For instance, the reaction of 1-methoxynaphtalene 4 with copper(II) bromide in refluxing benzene for 2 h. gave a mixture of 4-bromo-1-methoxy-naphtalene 5 (47 %) and 4,4 -dimethoxy-l,l -binaphtyl 6 (45 %). In contrast, in similar reaction using alumina-supported copper(II) bromide at 30°C, only dimerization occurred and no brominated compounds were obtained. 

Oxidative coupling of 2-bromo-4,6-di-im-butylphenol (202, Scheme 51) with potassium hexacyanoferrate(III) in a two-phase system consisting of aqueous potassium hydroxide and benzene affords the dibenzofuranone 203 by the mechanism indicated.The dibenzofuranone 203 is a convenient source of 1-dibenzofuranol (205). On boiling with isopropanol, compound 203 provides the tetra-tert-butyl-l-benzofuranol 204, which may be de-butylated by treatment with aluminum chloride in toluene. 1-Dibenzo-furanol (205) is also obtained by direct treatment of the dibenzofuranone 203 with aluminum chloride in toluene. With boiling methanol, however, compound 203 supplies the methoxy analog 206, which on mild debutylation affords 4-methoxy-1-dibenzofuranol (207). ... 

Another substitution reaction that is initiated by photochemical hydrogen abstraction is the replacement of the bromine atom in 2-bromo-8-methoxy-l, 4-naphthoquinone by an acyl group757. Irradiation of a solution in benzene of the quinone, butyraldehyde or capraldehyde and pyridine yields mixtures of acylated quinone and acylated hydro-quinone. In the first step, the excited quinone abstracts the aldehyde hydrogen atom and this is followed by bond formation between the acyl radical and C-2 of the quinone. The radical that is formed after departure of a bromine atom may either lose a hydrogen atom and yield acylated quinone or take up a hydrogen atom and become acylated hydro-quinone. 

Disubstituted 3,4-dihydroisoquinolines are easily prepared via cycli-zation of l-(2-aryl-2-isocyanoalkyl)-2-bromobenzenes in the presence of butyl lithium (Scheme 64) (13H389). The precursors to the l-(2-aryl-2-isocyanoalkyl)-2-bromobenzenes were themselves prepared l-bromo-2-(bromomethyl)benzenes and (l-isocyanoalkyl)benzenes in the presence of butyl lithium. The reaction sequence proceeded well with l-bromo-2-(bromomethyl)benzenes containing chlorides (47-58% yields) and methoxy groups (57-58% yields). Additionally, the (l-isocynaoalkyl)benzenes could contain various substituents without a decrease in yields. Trapping of the anion to introduce functionality at C-1 failed. 

Also obtained by reaction of sodium methoxide with 2-bromo-4-(2-bromo-l-methoxypropyl)-l-methoxy-benzene in boiling methanol for 2 h [6951],... 

Bromo-l-phthalimidopentane 3 was obtained in 72-82 g yield by refluxing 92 g of 1,4-dibromopentane 1, 55.5 g of potassium phthalimide 2, and 200 mL dry acetone on a steam bath for 30 h. Compound 3 (30 g) and 42 g 6-methoxy-8-aminoquinoline 4 refluxed at 130-135 °C for 6 h, extracted with benzene to separate insoluble 6-methoxy-8-aminoquinoline hydrobromide, the residue from evaporation of the benzene was refluxed with stirring with 100 mL of an alcoholic solution of 6 g hydrazine hydrate for 4 h, the solution was concentrated, made acidic to Congo red with 8 N hydrochloric acid, filtered, and washed with boiling water. The combined filtrate and washings was concentrated, made alkaline, extracted with benzene, and distilled in vacuo to give 20.5 g primaquine 6, which was treated with 19 mL 85% phosphoric acid in absolute ethanol, formed 42.5% primaquine diphosphate. 

Yel crysts, mp 206°. Can be prepd by heating 2,4,6-trinitro-5-methoxy-l,3-dimethyl-benzene for 2 hours with ale NH, in a sealed tube on a water bath(Ref 2) or by heating 5-bromo-2,4,6-trinitro-m-xylene with ale NH, at 130 Ref 3)... 

The intramolecular Diels-Alder reaction of 5-(3-butynyl)-3//-pyran[2,3-c]isoquinoline-3,6-dione (132) in boiling benzene afforded a pyrrolophe-nanthridone, which yielded 2-methoxy-anhydrolycorin-7-one (136). Hippadine (44) was synthesized by means of l-aza-T-oxa[3.3]sigmatropic rearrangement of A-(2-methoxycarbonylvinyloxy)-8,9-methylenedioxy-phenanthridin-6-one (133) (137) or by palladium-mediated intramolecular cyclization of 7-bromo-A-[(6-bromo-3,4-methylenedioxy)benzoyl]indoline (134) (138) (Fig. 10). 

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