Benzamidines, acidity

From Sigma 3-aminoethylcarbazole (AEC) acrylamide/bis-acrylamide (30%) 37.5 1 amino acids alumina bentonite benzamidine bovine fiver tRNA bovine serum albumin (BSA) creatine phosphate (CP) diethyl pyrocarbonate (DEPC) dithiothreitol (DTT) Escherichia coli MRE600 tRNA pyrophosphatase (Ppase) Ca++ salt of folinic acid, (5-formyl THF) IIHPHS K salt of phospho-enol pyruvic acid, (PEP) creatine phospho kinase (CPK) protease inhibitor cocktail for fungal and yeast extracts phenylmethylsulfonyl fluoride (PMSF) spermidine trihydrochloride Tween 20. 

The successfully generated chalcones could be cleaved by treatment with trifluoro-acetic acid or used for the subsequent synthesis of pyrimidines [45], Condensation of the polymer-bound chalcones with benzamidine hydrochloride under microwave irradiation for 30 min furnished the corresponding pyrimidines in good yields after TFA-induced cleavage. This new robust support/linker system for SPOT synthesis has been demonstrated to be compatible with a range of organic reactions and highly applicable for microwave conditions. 

Barbituric acid, 32, 7 Barium D-gulonate, 36, 39 Behenic acid, 37, 69 Beilstein test, 34, 38 Benzaldehyde, 30, 100 33, 70 34, 65 Benzaldehyde, p-AMINO, 31, 6 />-DIMETHYLAMINO-, 33, 27 Benzaldehyde, purification of, 33, 71 Benzalmalonic acid, ethyl ester, 37, S 4-Benzal-2-phenyl-5-oxazolone, 37, S Benzamidine, N,N -diphenyl-, 31, 48 N-phenyl-, 36, 64 Benzanilide, 31, 48... 

Auer et al. [134] presented an example for multilayer formation and controlled deposition of functionalized nanoparticles on SAM of mercaptohexadecanoic acid (MHA) using electrostatic interactions. As a pH-sensitive switchable linker between the SAM of MHA and negatively charged gold nanoparticles, bis-benzami-dine bolaamphiphiles having different alkyl spacers were used [135]. This strategy resulted in a potentially tunable and switchable property of the entire assembly. For example, the kinetics of adsorption as well as the final particle layer thickness can be controlled by the kind of bis-benzamidine used as the linker (Fig. 9.16). 

In strong hydrochloric acid, 51 is cleaved to benzil and benzamidine, perhaps via an analogous covalent hydrate" ethanoic acid similarly cleaves 44. ... 

Their stability is comparable with that of disubstituted oxadiazoles. For instance, 5-hydroxy-3-phenyloxadiazole is not decomposed by heating up to 300° and it is stable towards hydrochloric, nitric and sulfuric acid. The hydroxyl group cannot be substituted by chlorine when treated with phosphorus pentachloride or oxychloride at 100° 27, 28). It is reduced to benzamidine with hydroiodic acid and red phosphorus 81). The silver salt treated with ethyl iodide gives an N-ethyl derivative XLVI 28, 58, 59). 

Reduction of 5-amino-3-phenyloxadiazole with red phosphorus and iodhydric acid yields benzamidine (73). 

The pyrimido[4,5- ][l,2,4]triazines (6-azapteridines) 18a and 18b, shown in Scheme 18, were formed upon the reaction of the ethyl l,2,4-triazine-6-carboxylates 121 with benzamidine, a reaction which proceeds via the action of boiling acetic acid upon the characterized intermediate salt 122 <2003CCC965>. The same researchers (Scheme 19) also showed that the 5-amino-l,2,4-triazine-6-carboxamide 123 (R =OMe) can undergo reaction in neat benzaldehyde to furnish a low yield of the 6-azapteridine 18b. More importantly, the 5-amino-l,2,4-triazine-6-carboxamides 123 were found to undergo reaction with triethyl orthoformate to yield the 6-unsubstituted-3-arylpyr-imido[4,5-( ][l,2,4]triazines 18c and 18d, also shown in Scheme 19 (R = H) <2003CCC965>, one of only a few entries to such compounds. 

Benzamidine Picrate, C7HeN2+C6H3N307 mw 349.26, N 20.05% yel ndls, mp 228-33°. Can be prepd by evaporating a chloroformic soln of an equimolecular mixt of benzamidine and picric acid... 

Bacteriochlorins, 851 Barbituric acid metal complexes, 798 Barium alkoxides synthesis, 336 Barium complexes phthalocyanines, 863 porphyrins, 820 Becium homblei copper accumulation, 964 Benzaldehyde, 2-amino-self-condensation aza macrocycles from, 900 Benzamide, o-mercapto-metal complexes, 655 Benzamide oximes metal complexes, 274 Benzamidine, /V, V -diphenyl-metal complexes. 275 Benzene, 1,2-diamino-reactions with dicarbonyl compounds aza macrocycles from, 902 Benzene, 4 methylthionitroso-metal complexes, 804 Benzenedithiolates metal complexes, 605... 

The specificity pocket of trypsin can accommodate an arginine side chain of a polypeptide substrate or a benzamidine ion, which acts as a competitive inhibitor. Asp = aspartic acid. 

Computer-generated c-alpha tube model of the crystal structure of trypsin, seen from the same perspective as in figure 8.6(a). The coloring of the amino acid side chains and the inhibitor (benzamidine) is as in figure 8.6(a). (b) A close-up view of the active site of trypsin... 

Fig. 5 Complexes formed (a) between amidine groups in the functional monomer V,lV -diethyl-4-vinyl-benzamidine and carboxyl groups in the imprinting template IV-terephthaloyl-D-phenylglycine [82] and (b) between amidine groups in the imprinting template pentamidine and carboxyl groups in the functional monomer methacrylic acid [83]...

Barbituric acid, 32, 7 Benzaldehyde, 30,100 Benzaldehyde, amino, 31, 6 Benzamidine, N,N -diphenyl-, 31, 48 Benzanilide, 31, 48 Benzene, 31, 88 32, 10 Benzene (cHLORO-fert-BUTYL)-, 32, 90 Benzene, 2-chloro-1,3-dinitro-, 32,23 ETHYNYL-, 30, 72... 

The yellow crystals of compound 23 (Equation 6) are routinely obtained in a yield of 10-30%. However, replacement of benzamidine with fV,iV,./V -tris(trimethylsilyl)benzamidine gives compound 23 in a 60% yield without the requirement for any acid scavengers, thus improving the ease of the purification process <1989J(P1)2495>. The mechanism and labile nature of the trimethylsilyl groups is illustrated in Scheme 2 (modified from <1989J(P1)2495>). On the basis of these findings, silylated amidines remain an attractive route to dithiadiazoles. 

The usual synthetic method for the production of this system is the reaction of a 5,6-diamino-triazine with an organic acid equivalent. In Scheme 11 the activated nitrile (115) is displaced by benzamidine to give the intermediate (116) which is cyclized by base forming the imidazotriazine... 

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