Benz anthracene,7,12-dimethyl

Benz[a]anthracene, alkyl-43178-07-0 Benz[a]anthracene, dimethyl-... 

Moody JD, PP Fu, JP Freeman, CE Cemiglia (2003) Regio-and stereoselective metabolism of 7,12,dimethyl-benz[a]anthracene by Mycobacterium vanbaalenii PYR-1. Appl Environ Microbiol 69 3924-3951. 

Benzo[a]pyrene, oral 7,12-Dimethyl benz[a]anthracene Intravenous 100.0 (no effect) 4... 

Hoffman, D.J. and M.L. Gay. 1981. Embryotoxic effects of benzo[a]pyrene, chrysene, and 7,12-dimethyl-benz(a)anthracene in petroleum hydrocarbon mixtures in mallard ducks. Jour. Toxicol. Environ. Health 7 775-787. 

In animal studies, mirex, was tested at a dermal dose of 3.6 mg/kg 4 weeks in female CD-1 mice for tumor promoter activity and evidence of epidermal hyperplasia after initiation with 200 nmol/day 7,12-dimethyl-benz[a]anthracene (DMBA) for 1 week. Positive control mice were treated with 2 nmol/day of the phorbol ester tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA), following initiation with DMBA. A third group of mice were treated with both 3.6 mg/kg mirex and 2... 

A and B. This calculation is, of course, not very precise but it does correctly reflect the effect of methyl substitution on the basicity. Table 23 summarizes the values obtained in this way for all monomethyl derivatives and for the 7,12-dimethyl derivative of benz[a]anthracene (Mackor et al., 1956 Dallinga et al., 1958b). gives the figure of the total basicity, pA"(A) the value for ion A, pif(B) the value for ion B, and... 

Benzaldehyde, 4-ethoxy-3-methoxy-, 56, 44 Benzaldehyde, 4-ethoxy-3-methoxy-, ethylene acetal, 56, 44 Benzaldehyde, 4-isopropyl-, 55,10 Benz[e ] anthracene, 58, 15, 16 BENZENAMINE, 4-bromo-Ar, V-dimcthyl-3-(tnfluoromethyl)-, 55, 20 Benzene, bromo-, 55,51 Benzene, 1 bromo-4-chloro-,55, 51 Benzene, 4-bromo-l, 2-dimethyl, 55, 51 Benzene, l-bromo-4-fluoro-, 55, 51 Benzene, 1 -bromo-4-methoxy-, 55,51 Benzene, l-bromo-3-methyl-, 55, 51 Benzene, 4-(cr/-buty 1-1-ethyl, 55, 10 Benzene, chemical hazard warning, 58, 168 Benzene, chloro-,56, 86 Benzene, l-ethyl-4-isopropyl-, 55, 10... 

Iversen, O.H. (1988) Skin tumorigenesis and carcinogenesis studies with 7,12-dimethyl-benz[a]anthracene, ultraviolet light, benzoyl peroxide (Panoxyl gel 5%) and ointment gel. Carcinogenesis, 9, 803-809... 

The first arene oxides to be synthesized (1964) were obtained by the cyclization of appropriate seco derivatives. 0,0-Diformylbiphenyl derivatives, when treated with Mark s reagent [tris(dimethylamino)phosphine], gave arene oxides [Eq. (3)]. Thus K-region epoxides from phenanthrene and its analogs, benz[a]anthracene and its 7,12-dimethyl analog, have been prepared.34... 

One-electron oxidation to form cation radicals is the major pathway of activation for the most potent carcinogenic PAHs, whereas oxygenation is generally a minor pathway. For benz[a]pyrene and 7,12-dimethyl benz[a]anthracene, 80% and 90%, respectively, of the DNA adducts formed by rat liver microsomes or in mouse skin arise via the cation radicals (Cavaleri Rogan 1992). 

Sharoni, Y., Giron, E., Rise, M., and Levy, J. 1997. Effects of lycopene-enriched tomato oleoresin on 7,12-dimethyl-benz[a]anthracene-induced rat mammary tumors. Cancer Detect. Prev. 21, 118-123. 

Ellipticine and several derivatives were able to displace 7,12-dimethyl-benz[a]anthracene from binding to bovine and human serum albumin using the fluorescence-quenching technique (192,193). The site of binding of ellipticines appears to be on the hydrophobic regions of the enzyme. A fast kinetic experimental technique, namely, temperature-jump spectroscopy, has been developed in order to study the interaction of elliptinium, and other molecules, with biological macromolecules (194). 

DOT CLASSIFICATION 6.1 Label Poison SAFETY PROFILE Poison by ingestion, skin contact, subcutaneous, intravenous, and intraperitoneal routes. A severe skin and eye irritant. Questionable carcinogen with experimental neoplastigenic data by itself and with 7,12-dimethyl benz(a)anthracene. Combustible when exposed to heat or flame. Moderately explosive in the form of... 

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