Bence-Jones protein formation

Klafki, H. W., Pick, A. I., Pardowitz, I., Cole, T., Awni, L. A., Barnikol, H. U., Mayer, F., Kratzin, H. D., and Hilschmann, N. (1993). Reduction of disulfide bonds in an amyloidogenic Bence Jones protein leads to formation of amyloid-like fibrils in vitro. Biol. Chem. Hoppe Seyfer374, 1117-1122. 

Isophorone produced kidney effects in male rats in the NTP (1986) study. Strasser (1988) found that isophorone caused protein droplet formation in the kidneys of male rats, suggesting that isophorone can induce protein nephropathy. Alden (1986) discussed the possibility that proteinuric humans and humans with low molecular weight protein nephropathy, such as people with multiple myeloma (Bence-Jones protein) or mononuclear cell leukemia (lysozyme), may be more susceptible to chemically-induced protein nephropathy. He concluded, however, that this syndrome is probably specific to the male rat. 

Isobe T, Osserman EF (1974) Patterns of amyloidosis and their association with plasma cell dyscrasias, monoclonal immunc lobulins and Bence Jones proteins. N Engl J Med 290 473-477 Ivanova Ml, Gingery M, Whitson LJ, Eisenba-g D (2003) Role of the C-terminal 28 residues of beta 2-microglobulin in amyloid fibril formation. Biochemistry 42 13536-13540 Iwata K, Fujiwara T, Matsuki Y, Akutsu H, Takahashi S, Naiki H, Goto Y (2006) 3D structure of amyloid protofilaments of beta 2-micrc lobulin fragment probed by solid-state NMR. Proc Natl Acad Sci USA 103 18119-18124... 

Fig. 3.15. Variations and character of accessible surface area as a result of formation of secondary structures in six proteins pancreatic trypsin inhibitor (PTI), calcium binding protein (CBP), Bence-Jones protein REI (VIM), elastase (ELA), thermolysin (TLS), and carboxy-peptidase A (CPA). (A) Surface which remains accessible (B) surface which becomes buried. The partition, polar, charged, and nonpolar surface is indicated in all cases (according to Chothia, 1976).

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