Cholinesterase inhibitors behavioral toxicity

EEG and behavioral effects were modified in a parallel manner by the concurrent administration of antagonistic drugs. For Instance, when patients who exhibited a toxic delirium to Dlcran or atropine were given cecrafaydroamlnoacridlne, a cholinesterase inhibitor, the stupor was relieved and the EEG showed a decrease in both slow and fast frequencies. 

Bnccafnsco, J. J., J. H. Graham, and R. S. Aronstam. 1988a. Behavioral effects of toxic doses of soman, an organophosphate cholinesterase inhibitor, in the rat protection afforded by clonidine. Pharmacol. Biochem. Behav. 29(2) 309-13. 

B40. Buccafusco, J. J., Graham, J. H., VanLingen, J., and Aronstam, R. S., Protection afforded by clonidine from the acute and chronic behavioral toxicity produced by the cholinesterase inhibitor soman. Neurotoxicol Teratol 11, 39 4 (1989). 

Bushnell, P.J., Moser, V.C., 2006. Behavioral toxicity of cholinesterase inhibitors. In Gupta, R.C. (Ed.), Toxicology of Organophosphate and Carbamate Compounds Academic Press/Elsevier, Amsterdam, pp. 347-360. 

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