BCR-ABL oncogene

M2. McLaughin, J., Chianese, E., and Witte, O. N., Alternative forms of the BCR-ABL oncogene have quantitatively different potencies for stimulation of immature lymphoid cells. Mol. Cell. Biol. 9, 1866-1874 (1989). 

Van Etten RA. Mechanisms of transformation by the BCR-ABL oncogene new perspectives in the post-imatinib era. Leak Res 2004,2 Suppl LS21-28. 

Snyder, D.S., Wu, Y., McMahon, R., Yu, L., Rossi, J.J. and Forman, S.J. (1997) Ribozymemediated inhibition of a Philadelphia chromosome-positive acute lymphoblastic leukemia cell line expressing the pi 90 bcr-abl oncogene. Biol. Blood Marrow Transplant., 3, 179-186. 

At present, we can induce CML in mice with high efficiency, shown by 100% induction of CML in mice (14). The same CML disease could be induced in most of the inbred mouse strain including C57BL/6, BALB/c, and viable gene knockout mice strains (15). Because all recipients develop CML with a short latency (about 3 weeks), this provides an excellent model for evaluating therapeutic agents for CML treatment (15). As CML is derived from the hematopoietic stem cells which harbor BCR-ABL oncogene, CML leukemia stem cells can also be studied in this model (15). In conclusion, this retroviral model system pro-... 

Li, S., Ilaria, R. L., Jr., Million, R. P., Daley, G. Q. and Van Etten, R. A. (1999) The P190, P210, and P230 forms of the BCR/ABL oncogene induce a similar chronic myeloid leukemia-like syndrome in mice but have different lymphoid leuke-mogenic activity. J Exp Med 189, 1399-1412. 

Goga A, McLaughlin J, Afar DE, Safran DC, Witte ON. Alternative signals to RAS for hematopoietic transformation by the BCR-ABL oncogene. Cell. 1995 82 981-8. 

The Philadelphia translocation t(9 22) (q34 qll) or Philadelphia chromosome is a chromosomal defect resulting in gene fusion of the BCR and ABL genes. The resultant fusion gene is the BCR-ABL oncogene. The Philadelphia chromosome is a cytogenetic abnormality seen in 95 % of chronic myeloid leukemia patients and 15-30 % of adults with acute lymphoblastic leukemia. 

Lugo, T.G., PendergasL A., Muller, A.J., and Witte, O.N. (1990) Tyrosine kinase activity and transformation potency of bcr-abl oncogene products. Science, 247, 1079-1082. 

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