Basic principles, drug action

Mutschler E, Derendorf H. Drug actions—basic principles and therapeutic aspects. Stuttgart Medpharm Scientific Pub. Boca Raton CRC Press 1995. 

The potential of psychoactive TDM to improve therapy has been limited to date because many clinicians lack basic PK training and pharmaceutical marketing departments actively discourage TDM of their drugs. In order to correct this situation, clinicians must appreciate the basic PK principles necessary to correctly order and interpret TDM results, as well as to understand or predict drug actions in their individual patients. 

High dilutions of drugs have been used on human patients for a couple of centuries, and animal experimentation has been done only to confirm their therapeutic effects and study their mode of action. High dilutions have been found to produce effects on such animals as rats, mice, birds, toads and fishes. The basic principle is to create a disease in the animals and test appropriate remedies on them. Some models like catalepsy and righting reflex ones are non-sacrifice animal models which can be easily used to test the biological effects of potentized drugs. Potentized Nux vomica significantly reduced alcohol intake in rats and reversed to some extent... 

Gotte M. Inhibition of HIV-1 reverse transcription basic principles of drug action and resistance. Expert Rev Anti Infect Ther. 2004 2 707-716. 

Before considering the pharmacology of any particular class of drugs, it is important to understand the basic underlying principles of drug action. The following two chapters in this section will deal with an important subject traditionally covered in the area of pharmacology known as pharmacokinetics (i.e., time-related factors such... 

Mutschler, E. and Derendorf, H. (eds) (1995) Drug Actions Basic Principles and Therapeutic Aspects. Boca Raton, FL CRC Press. 

Basic pharmacologic principles apply as much to drug interactions as to drug actions. Each kinetic property—absorption, distribution, metabolism (biotransformation), and excretion—is potentially affected by the presence of coadministered medications. Drug interactions follow a variable time-course pattern, from immediate to delayed. Consequently, it is important to remember that several weeks may elapse before the effects of an interactive combination are evident. 

Johanson, C. E. (1992). BicK hcmical mechanisms and pharmacological principles of drug action. In J. Grabowski 8c G. R. VandenBos (Eds.), Master lecture scries. Psychopharmacolpffy Basic mechanisms and applied interventions (pp. 11-58). Washington, DC American Psychological Association. 

Jawclx. E. Principles of unliniicrubial drug action. In Kalxiing. B. G (ed.). Basic und Clinical Pharmacology. 6th ed. Norwalk. CT. Apple-ton Lange. 1995. 

Rane A. Basic principles of drug disposition and action in infants and children. In Yaffe IF, ed. Pediatric Pharmacology Therapeutic Principles... 

Based on the Socratic principle that the best way to learn is to ask the right questions, Pharmacology Secrets introduces students and practitioners to an important new resource for learning. In fifty chapters written in the clear and engaging format of the Secrets Series , the authors cover the basic mechanisms of drug actions and provide a comprehensive review of clinical drug therapy. This text is excellent for preparing for course work and exams and is a valuable refresher for all health care professionals. Features include ... 

The second edition of this exceptional book provides a comprehensive understanding of the mechanisms of action involved in psychiatric pharmacotherapy. Using imaginative colorful double-page spreads, this exceptional book presents state-of-the-art information on all the basic principles of psychiatric pharmacotherapy, abused substances, drug interactions, and treatment strategies. 

The basic kinetic concepts in the body system initially came from the study of drug actions, or pharmacokinetics. Nowadays, these principles are usually apphed to study or predict the movement of a substance in the organism, such as a toxin, an environmental pollutant, or even a phytochemical, constituting what is called biokinetics. 

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