Pharmacology, basic principles

Melmon KL, Morrelli HP (1972) Clinical pharmacology basic principles in therapeutics. Macmillan, New York... 

Melmon KL, Morelli HF, Hoffman BB, Nierenberg DW. Clinical Pharmacology—basic principles in therapeutics. S ed. New York McGraw-Hill 1992. 

Caruthers SG, Hoffman BB, Melmon KL, Nier-enberg DW. Melmon and Morelli s Clinical Pharmacology—Basic Principles in Therapeutics. 4th ed. New York McGraw-Hill 2000. 

Glazener, F. S. 1992. Adverse drug reactions. In Melmon and Morrelli s clinical pharmacology Basic principles in therapeutics 3rd ed. D. W. Nierenberg, eds.. New York McGraw-Hill. 

Vestal, R. E., S. C. Montamat, and C. P. Nielson. 1992. Drugs in special patient groups The elderly. In Melmon and Morrelli s clinical pharmacology Basic principles in therapeutics, 3rd ed., K. L. Melmon, H. F. Morrell , B. B. Hoffman, and D. W. Nierenberg, eds. New York McGraw-Hill. 

Sheiner LB, Tozer TN (1978) Clinical pharmacokinetics The use of plasma concentration in drugs. In Melmon KL, Morelli HP (eds), Clinical Pharmacology Basic Principles of Therapeutics. Macmillan, New York, pp. 71-109. 

McFadden ER Jr, Austen KF (1977) Asthma. In Thom GW, Adams RD, Braunwald E, Isselbacher KJ, Petersdorf RG (eds) Harrison s priciples of internal medicine, 8th edn. McGraw-Hill Kogakusha, Tokyo, pp 1349-1354 Meyer UA (1978) Role of genetic factors in the rational use of drugs. In Melmon KL, Morelli HF (eds) Clinical pharmacology. Basic principles in therapeutics, 2nd edn. Macmillan, New York, pp 913-929... 

B22. Brodie, B. B., Basic principles in development of methods for drug assay. In Concepts in Biochemical Pharmacology (B. B. Brodie and J. R. Gillette, eds.). Handbook of Experimental Pharmacology, Vol. 28, Part 2, pp. 1-8. Springer-Verlag, Berlin and New York, 1971. 

Katzung PHARMACOLOGY, 9e > Section VIII. Chemotherapeutic Drugs > Chapter 52. Basic Principles of Antiparasitic Chemotherapy > ... 

Mendelson WB. Hypnotics Basic mechanisms and pharmacology. In Principles and Practice of Sleep Medicine, 3rd ed., WB Saunders, 2000, Philadelphia, PA... 

The expectation of combined effects from mixture exposure is most often founded in the basic principles of toxicology and pharmacology (Loewe and Muischnek 1926a Bliss 1939 Plackett and Hewlett 1952). The first strictly pharmacological ideas formulated (Loewe and Muischnek 1926a) were supplemented by biometrical considerations. Later, Bliss (1939), a biologist and a biometrician, provided the first consistent framework, as depicted in Table 5.2 (Plackett and Hewlett 1952). In this framework, the main ideas focused on the presence or absence of interactions (commonly referred to as interactive and noninteractive joint action) with respect to responses observed in test organisms, and the presence of the same or a different mode of action. 

These extended case studies complement the basic information presented in Chapters 1 to 40. They reinforce basic principles of pharmacology, such as the role of patient factors in empiric antimicrobial therapy Most of the cases provide clinical information obtained from a single patient some cases describe a composite of typical features derived from several patients. These cases illustrate simple pharmacologic principles, such as consideration of kidney function in drug dosing—concepts useful in answering examination questions, and in the clinics. 

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