Basic Molecular Mechanisms of Pituitary Tumor Formation

Insights into the basic molecular mechanisms of pituitary tumor formation 

Proteomics provides a unique insight on a global protein-system level into the basic molecular mechanisms that participate in the formation of a pituitary adenoma. Through our series of comparative proteomics, we have confirmed our initial hypothesis that the proteome differs between pituitary controls and adenomas— many DEPs were found that correlated to the comparative transcriptomics data and to the corresponding biological systems. Those protein systems summarized in Table 4 provide a hint of the multiple protein systems that are involved in the formation of a pituitary adenoma. Those DEPs provide a basis to determine the activities that are critical for the observed changes in expression—whether they occur either at the mRNA or protein level or by PTM, and whether they are involved in the formation of a human pituitary adenoma. 

Those data reveal an overview of multiple protein systems that could participate in human pituitary adenomas. 

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