Comparative transcriptomics

Comparative Transcriptomic Analysis/Digital Gene-Expression Profiling... 

An important issue that continues to arise in gene expression studies is the reportedly poor correlation between mRNA and protein levels reported for some studies that compare transcriptomic and proteomic datasets from the... 

Suzuki, M., Hayshizaki, Y. 2004. Mouse-centric comparative transcriptomics of protein and non-coding RNAs. BioEssays 26, 833-843. 

Rossouw, D., Naes, T., Bauer, F. (2008). Linking gene regulation and the exo-metabolome a comparative transcriptomics approach to identify genes that impact the production of volatile aroma compounds in yeast. BMC Genomics, 9, 530. http //dx.doi.org/10.1186/1471-2164-9-530. 

Bonizzoni M, Afrane Y, Dunn WA, Atieli FK, Zhou G, Zhong D, Li J, Githeko A, Yan G (2012) Comparative transcriptome analyses of deltame-thrin-resistant and -susceptible Anopheles gambiae mosquitoes from Kenya by RNA-SEq. PLoS One 7 e44607... 

Comparative proteomics vs. comparative transcriptomics in human pituitary adenomas... 

Proteomics provides a unique insight on a global protein-system level into the basic molecular mechanisms that participate in the formation of a pituitary adenoma. Through our series of comparative proteomics, we have confirmed our initial hypothesis that the proteome differs between pituitary controls and adenomas— many DEPs were found that correlated to the comparative transcriptomics data and to the corresponding biological systems. Those protein systems summarized in Table 4 provide a hint of the multiple protein systems that are involved in the formation of a pituitary adenoma. Those DEPs provide a basis to determine the activities that are critical for the observed changes in expression—whether they occur either at the mRNA or protein level or by PTM, and whether they are involved in the formation of a human pituitary adenoma. 

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