Bactericidal-permeability-increasing

The genes coding for CETP and PLTP belong to one gene family, which also includes lipopolysaccharide-binding-protein (LBP) and bactericidal/permeability-increasing-protein (BPI). This common descent not only becomes clear from a considerable sequence similarity (45-65% homology at the cDNA level), but also from substantial conservation of exon/intron transitions. 

Bactericidal permeability increasing protein Increases antibiotic activity Septic shock, antiangiogenic... 

A bactericidal permeability increasing protein found inside human neutrophils has been investigated as a potent endotoxin neutralizing agent in the treatment of septic shock. It has also been shown to enhance the activity of antibiotics, suggesting a potential use in treating antibiotic-resistant infections (28). 

Weersink, A.J.L., van Kessel, K.P.M., van den Tol, M.E., van Strijp, J.A.G., Torensma, R., Verhoef, J., Elsbach, R, Weiss, J. Human granulocytes express a 55 kDa lipopolysaccharide-binding protein on the cell surface that is identical to the bactericidal/permeability-increasing protein. J Immunol 150 (1992) 253-263. 

Non-vaccine generated anti-endotoxin reagents that bind and/or neutralize LPS, such as bactericidal permeability increasing protein (BPI), endotoxin neutralizing protein (ENP), and cationic peptide 18 conjugated to immunoglobulin G (CAP 18-IgG) have been developed for the adjunctive therapy of sepsis, but only BPI has progressed to clinical trials (Levin et al., 2000). 

Fig. 15.2 Levels of targeting endotoxin (BP binding-protein BPI bactericidal/permeability increasing protein HLF human lactoferrin PMX-HF polymyxin B hemoperfusion)...

Calvano, S.E., Thompson, W.A., Marra, M.N., Coyle, S.M., de Riesthal, H.F., Trousdale, R.K., Barie, P.S., Scott, R.W., Moldawer, L.L., Lowry, S.F. Changes in polymorphonuclear leukocyte surface and plasma bactericidal/permeability-increasing protein and plasma lipopolysaccharide binding protein during endotoxemia or sepsis. Arch Surg 129 (1994) 220-226. 

Demetriades, D., Smith, J.S., Jacobson, L.E., Moncure, M., Minei, J., Nelson, B.J., Scannon, P.J. Bactericidal/permeability-increasing protein (rBPI21) in patients with hemorrhage due to trauma Results of a multicenter phase II clinical trial. rBPI21 Acute Hemorrhagic Trauma Study Group. J Trauma 46 (1999) 667-676 discussion 676-677. 

Elsbach, P., Weiss, J. The bactericidal/permeability-increasing protein (BPI), a potent element in host-defense against gram-negative bacteria and lipopolysaccharide. Immunobiology 187 (1993) 417—429. 

Elsbach, P., Weiss, J., Doerfler, M., Shu, C., Kohn, F., Ammons, W.S., Kung, A.H., Meszaros, K.K., Parent, J.B. The bactericidal/permeability increasing protein of neutrophils is a potent antibacterial and anti-endotoxin agent in vitro and in vivo. Prog Clin Biol Res 388 (1994) 41-51. 

Giroir, B.P., Scannon, P.J., Levin, M. Bactericidal/permeability-increasing protein—lessons learned from the phase III, randomized, clinical trial of rBPI21 for adjunctive treatment of children with severe meningococcemia. Crit Care Med 29 (2001) S130-S135. 

Jiang, J., Xie, G., Liu, D., Zhu, P., Wang, Z., He, Y., Zhou, J., Xu, H. Effect of bactericidal /permeability-increasing protein on sepsis induced by intra-abdominal infection in rats. Chin J Traumatol 2 (1999a) 84-86. 

Levy, O., Martin, S., Eichenwald, E., Ganz, T., Valore, E., Carroll, S.F., Lee, K., Goldmann, D., Thome, G.M. Impaired innate immunity in the newborn Newborn neutrophils are deficient in bactericidal/permeability-increasing protein. Pediatrics 104 (1999) 1327-1333. 

Weiss, J., Elsbach, P., Shu, C., Castillo, J., Grinna, L., Horwitz, A., Theofan, G. Human bactericidal/permeability-increasing protein and a recombinant NH2-terminal fragment cause killing of serum-resistant gram-negative bacteria in whole blood and inhibit tumor necrosis factor release induced by the bacteria. J Clin Invest 90 (1992) 1122-1130. 

Synthetic peptides comprising amino acids 85-99 (domain II) and 148-161 (domain HI) of Bactericidal/ Permeability-increasing protein (BPI)... 

Dentener MA, Franco GJ, Hiemstra PS, Tool AT, Verhoeven AJ, Vandenabeele P, Buurman WA Bactericidal/permeability-increasing protein release in whole blood ex vivo Strong induction by lipopolysaccharide and tumor necrosis factor-alpha. J Infect Dis 1997 175 108-117. 

Colgan SP, Serhan CN, Parkos CA, Delp-Archer C, Madara JL Lipoxin A4 modulates transmigration of human neutrophils across intestinal epithelial monolayers. J Clin Invest 1993 92 75-82. Canny G, Levy O, Furuta GT, Narravula-Alipati S, Sisson RB, Serhan CN, Colgan SP Lipid mediator-induced expression of bactericidal/permeability-increasing protein (BPI) in human mucosal epithelia. Proc Natl Acad Sci USA 2002 99 3902-3907. 

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