Bacterial vaginosis treatment

Ahmed-Jushuf IH, Shahmanesh M, Arya OP The treatment of bacterial vaginosis with a 3-day course of 2% clindamycin cream Results of a multicenter, double-blind, placebo-controlled trial. Genitourin Med 1995 71 254— 266. 

Neri A, Rabinerson D, Kaplan B Bacterial vaginosis Drugs versus alternative treatment. Obstet Gynecol Surv 1994 49 809-813. 

Palazzini E, Desai S Pilot study on the in vivo efficacy of two formulations of rifaximin for the treatment of bacterial vaginosis. Bologna, Alfa Wassermann/Schiapparelli Searle, 1992. 

Unlabeled Uses Treatment of bacterial vaginosis, grade 111-lV decubitus ulcers with anaerobic infection, Flelicobacler pytori-associated gastritis and duodenal ulcer, inflammatory bowel disease topical treatment of acne rosacea... 

Metronidazole is indicated for treatment of anaerobic or mixed intra-abdominal infections, vaginitis (trichomonas infection, bacterial vaginosis), C difficile colitis, and brain abscess. The typical dosage is 500 mg three times daily orally or intravenously (30 mg/kg/d). Vaginitis may respond to a single 2-g dose. A vaginal gel is available for topical use. 

Miphil (Columbia Laboratories Inc., Livingston, NJ, USA), a marketed bioadhesive gel based on polycarbophil and capable of reducing vaginal pH, has been used in combination with oral tinidazol for the treatment of bacterial vaginosis. In a multicenter, randomized, investigator-blinded, controlled clinical trial, the combination of the antibiotic with the... 

Polycarbophil-based bioadhesive tablets of metronidazole were tested for adhesion on bovine submaxillary mucin [74]. In a more recent study, metronidazole tablets based on a mixture of modified starch-polyacrylic acid showed an increased potential for the treatment of bacterial vaginosis [75]. 

Baloglu, E., et al. 2003. A randomized trial of a new ovule formulation of ornidazole for the treatment of bacterial vaginosis. J Clin Pharm Ther 28 131. 

Mikamo, H., Kawazoe, K., Izumi, K., Watanabe, K., Ueno, K., and Tamaya, T. (1997), Comparative study on vaginal or oral treatment of bacterial vaginosis, Chemotherapy, 43,60-68. 

Fiorilli,A.,Molteni,B.,and Milani, M. (2005), Successful treatment of bacterial vaginosis with a policarbophil-carbopol acidic vaginal gel Results from a randomised doubleblind, placebo-controlled trial, Eur. J. Obstet. Gynecol. Reprod. Biol., 120,202-205. 

Clindamycin also is indicated for the treatment of bacterial vaginosis Its efficacy as a 2% cream is similar to oral metronidazole treatment. Measurable... 

Fischbach, F. Petersen, E. Weissenbacher, E. Martins, J. Hosmann, J. Mayer, H. Efficacy of clindamycin vaginal cream versus oral metronidazole in the treatment of bacterial vaginosis. Obstet. Gynecol. 1993, 82, 405-410. 

Erkkola R, Jarvinen H. Single dose of ornidazole in the treatment of bacterial vaginosis. Ann Chir Gynaecol Suppl 1987 202 94-6. 

In 233 women with bacterial vaginosis, a 3-day regimen of clindamycin (intravaginal ovules, 100 mg/day) was as effective as a 7-day regimen of oral metronidazole (500 mg bd) and better tolerated (4). Treatment-related adverse events were reported more often with metronidazole, and systemic symptoms, such as nausea and taste disturbance, accounted for most of the difference between the groups. 

Metronidazole has been formulated as a vaginal gel (0.75%) for the treatment of bacterial vaginosis. A single daily 5-day regimen has been approved by the FDA and has been shown to be as effective as oral metronidazole (1). 

Leitich H, Bmnbauer M, Bodner-Adler B, et al. Antibiotic treatment of bacterial vaginosis in pregnancy A meta-analysis. Am 1 Obstet Gynecol 2003 188 752-758. 

Clindamycin is an antibiotic/antiinfective/lincosamide, which suppresses bacterial protein synthesis. It is indicated in the treatment of serious infections caused by susceptible strains of anaerobes, streptococci, staphylococci, and pneumococci treatment of acne vulgaris (topical use) treatment of bacterial vaginosis (vaginal use) in nonpregnant women and second- or third-trimester pregnant women (Cleocin and ClindaMax only). 

Clindamycin cream (2%) for the treatment of bacterial vaginosis caused vaginal discharge in 4.6% of patients and vulvovavginal pruritus in 8.5%. No serious adverse events were reported [90 ]. 

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