Bacterial glycosidases

Since the colonic bacterial enzymes are capable of hydrolyzing various di- and oligosaccharides (glycosidases) and polysaccharides (polysaccharidases), the chi-tosanolytic activities of rat cecal and colonic enzymes on chitosan was investigated. The results revealed that the rat bacterial enzymes have the ability to degrade chitosan, depending on both the Mw and DA of the chitosan sample [171]. 

Shiga toxin, a bacterial toxin produced by Shigella dysenteriae belonging to the AB5 toxins family. It is structurally related to verotoxin and cholera toxin. Shiga toxin is composed of two subunits. The monomeric A-subunit has a N-glycosidase activity causing inhibition of protein synthesis and cell death. The B-subunit is a homopentamer which is responsible for receptor binding, internalization and intracellular transport of the holotoxin [E. A. Meritt, W. G. Hoi, Curr. Opin. Struct. Biol. 1995, 5, 165 D. G. Pina et al., Biochim. Biophys. Acta 2007, 1768, 628]. 

Colon and rectum 13-68h 7.0-7.5 Broad spectrum of bacterial enz3rmes (glycosidases, azoreductase, polysaccharidases)... 

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