Bacterial, genetic control

N. Sudarsan, I. Jona, J.K. Wickiser, R.R. Breaker, New RNA motifs suggest an expanded scope for riboswitches in bacterial genetic control, Proc. Natl. Acad. Sci. U.S.A. 2004, 101, 6421-6426. 

Romby, P. Springer, M. (2003) Bacterial translational control at atomic resolution. Trends Genet. 19, 155-161. 

Moreover, this enzyme is the most extensively studied example of induced enzyme-formation, and it has been employed for investigating the mechanism of specific protein synthesis and the genetic control thereof. An understanding of the constitution of the active center of this enzyme might help in identifying, in the bacterial cell, the apparatus which controls its production. 

One striking similarity between iron metabolism in animals and bacteria is that both contain ferritin (63). Bacterial ferritin, or bacfer, resembles ferritin in a number of respects (Section IV), but a key difference is that bacfer is also a 6-type cytochrome (129), cytochrome bi (126). Thus the question arises Is it primarily a cytochrome or primarily an iron storage protein This question opens up a large number of avenues of research, some of which are described in Section IV, that we believe will help define further how animal ferritin functions. One important area is that of genetic control of bacfer expression. 

G2. Garen, A., Genetic control of the bacterial enzyme, alkaline phosphatase. In Microbial Genetics (W. Hayes and R. C. Clowes, eds.), pp. 239-247. Cambridge Univ. Press, London and New York, 1960. 

In the past many persons attributed abnormally high oil secretion and the development of acne to the afflicted individual s diet and hygiene. However, current research suggests that oil secretion is under genetic control, primarily related to the abihty of androgenic hormones to stimulate oil secretion. The bacterial species Propionibacterium acnes is believed to play a role in converting acne into an inflammatory condition. Stress and the use of certain cosmetics may also be contributing factors. 

Inohara O, Ghamaillard M, McDonald G, Nunez G 2005 NOD-LRR proteins role in host-microbial interactions and inflammatory disease. Annu Rev Biochem 74 355—383 Lam-Yuk-Tseung S, Gros P 2003 Genetic control of susceptibility to bacterial infections in mouse models. Cell Microbiol 5 299-313... 

GENETIC CONTROL OF BACTERIAL PURINE PHOSPHORIBOSYL-TRANSFERASES AND AN APPROACH TO GENE ENRICHMENT... 

Such comparative investigations will certainly involve questions of evolution, taxonomy and bacterial genetics. For example Makela [69] showed that the presence of abequose in group B of Salmonella is genetically controlled by two alleles present on the same locus of the genome. Thus, it appears that the K.W. scheme and the W.E. scheme are helpful for a genetic classification. 

---