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Background electrolyte additive composition

Another division of the factors can be made into mixture-related, quantitative (continuous), or qualitative (discrete) factors (4,5,16,18,24). A mixture-related factor in CE is usually related to a mixture of solvents, for example, the composition of the background electrolyte solution. A quantitative factor can vary on a continuous scale, for example, the buffer pH, the electrolyte concentration, the additive concentration, the capillary temperature, or the voltage. A qualitative factor, on the other hand, varies on a discrete nominal scale, for example, batch or manufacturer of a reagent, solvent, or capillary. [Pg.20]

Several studies have employed chemometric designs in CZE method development. In most cases, central composite designs were selected with background electrolyte pH and concentration as well as buffer additives such as methanol as experimental factors and separation selectivity or peak resolution of one or more critical analyte pairs as responses. For example, method development and optimization employing a three-factor central composite design was performed for the analysis of related compounds of the tetracychne antibiotics doxycycline (17) and metacychne (18). The separation selectivity between three critical pairs of analytes were selected as responses in the case of doxycycline while four critical pairs served as responses in the case of metacychne. In both studies, the data were htted to a partial least square (PLS) model. The factors buffer pH and methanol concentration proved to affect the separation selectivity of the respective critical pairs differently so that the overall optimized methods represented a compromise for each individual response. Both methods were subsequently validated and applied to commercial samples. [Pg.98]

Fillet M., Servais A.C., Crommen J., Effects of background electrolyte composition and addition of selectors on separation selectivity in nonaqueous capillary electrophoresis. Electrophoresis, 24, 1499-1507 (2003). [Pg.171]

To optimize such separation systems, on the one hand the nature and concentration of the chiral selector can be varied, while on the other hand the pH and organic additives (e.g., lower alcohols) make it possible to modify retention times and resolution. For electrophoretic applications, the electric field strength and the composition of the buffer ( background electrolyte , BGE) can also support enantiomer separations. [Pg.461]

Three comprehensive books on porous silicon have been published, wherein detailed information can be found related to silicon anodization (Canham 1997 Lehman 2002 Sailor 2012a). The topics covered include dissolution chemistries and the dependences of porosity, pore morphology, and pore size distribution on various parameters (e.g., wafer type/doping, electrolyte composition, current density, time) additionally, different types of electrochemical cells are discussed (Lehman 2002 Sailor 2012a), as well as some of the more practical aspects related to anodization (Sailor 2012a e.g., wafer preparation, equipment and instrumentation, health and safety). The reader is referred to these references for essential background reading. [Pg.561]


See other pages where Background electrolyte additive composition is mentioned: [Pg.520]    [Pg.39]    [Pg.134]    [Pg.134]    [Pg.687]    [Pg.190]    [Pg.358]    [Pg.63]    [Pg.278]    [Pg.62]    [Pg.730]    [Pg.283]    [Pg.118]    [Pg.8]    [Pg.166]   


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