B-lymphocytes proliferation

Cerqueira, F. Corderio-Da-Silva, A. Gaspar-Marques, C. Simoes, F. Pinto, M. M. M. Nascimento, M. S. J. Effect of abietane diterpenes from Plectranthus grandidentatus on T- and B-lymphocyte proliferation. Bioorg. Med. Chem. 2004, 12, 217-223. 

The specific immunosuppressives include cyclosporine and tacrolimus. Although chemically not related and with different biochemical targets they both specifically inhibit cytotoxic T-cell and T-helper cell dependent B-lymphocyte proliferation. 

IL-2 (Proleukin) is a cytokine that promotes the proliferation, differentiation, and recruitment of T and B lymphocytes, natural killer cells, and thymocytes. Human recombinant IL-2 is designated as rIL-2. rIL-2 binds to IL-2 receptors on responsive cells and induces proliferation and differentiation of T helper cells and T cytotoxic cells. It also can induce B-lymphocyte proliferation, activate macrophage activity, and augment the cytotoxicity of natural killer cells. 

Acetaldehyde, benzene, butyraldehyde, iso-prene, styrene, and toluene in mouse lymphocytes cell culture for 3 hours produced no effect on either viability or proliferation. Lormaldehyde, catechol, acrylonitrile, propionaldehyde, and hydroquinone significantly inhibited T-lymphocyte and B-lymphocyte proliferation, inhibitory concentration (IC )jo 1.19 x 10" M to 8.20 x 10" M. Acrolein and crotonaldehyde inhibited T-cell and B-cell proliferation and acted on viability with ICjp 2.06 x 10 M to 4.26 X 10" M. Mixtures of acrolein, formaldehyde, and propionaldehyde or crotonaldehyde interactive effects at 0.5 and 1 x ICjo were observed " . 

Luo, H., Hofstetter, H., Banchereau, J. and Delespesse, G. (1991). Cross-linking of CD23 antigen by its natural ligand (IgE) or by anti-CD23 antibody prevents B lymphocyte proliferation and differentiation. J. Immunol. 146, 2122-2129. 

IL-14 T-lymphocytes proinflammatory cytokines, directs IgE isotype switching Induces B-lymphocyte proliferation, inhibits secretion of Igs... 

P-Carotene (2) also might represent the T- and B-lymphocyte proliferation, T-helper cell proliferation, enhancement of macrophage function, and more potent natural killer (NK) cell cytotoxicity. From these facts, kiwifruit carotenoids might have immune response by antioxidative effects (Figure 9) [51, 52, 53, 54, 55],... 

Two peaks of their frequencies are seen one early, during the first months following transplantation (0.5% the first year), and the other years later (0.04% and per year). The greater majority of these lymphomas start as B-lymphocyte proliferations. 

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