B-Alanine

Glycine Spinal interneurons and some brain stem interneurons Taurine, B-alanine Strychnine Inhibitory t CI conductance... 

Approximately 6% of a topically applied dose is absorbed—an amount insufficient to produce adverse systemic effects. Most of the absorbed drug is metabolized and excreted as carbon dioxide, urea, and ct-fluoro-B-alanine. A small percentage is eliminated unchanged in the urine. Fluorouracil inhibits thymidylate synthetase activity, interfering with the synthesis of DNA and, to a lesser extent, RNA. These effects are most marked in atypical, rapidly proliferating cells. 

Sulfasalazine, balsalazide, and olsalazine contain 5-ASA bound by an azo (N=N) bond to an inert compound or to another 5-ASA molecule (Figure 62-8). In sulfasalazine, 5-ASA is bound to sulfapyridine in balsalazide, 5-ASA is bound to 4-aminobenzoyl-B-alanine and in olsalazine, two 5-ASA molecules are bound together. The azo structure markedly reduces absorption of the parent drug from the small intestine. In the terminal ileum and colon, resident bacteria cleave the azo bond by means of an azoreductase enzyme, releasing the active 5-ASA. Consequently, high concentrations of active drug are made available in the terminal ileum or colon. 

B-Alanine [107-95-9] NI 89.1, m 205°(dec). Crystd from filtered hot saturated aqueous soln by adding four volumes of absolute EtOH and cooling in an ice-bath. Recrystd in the same way and then finally, crystd from a warm saturated soln in 50% EtOH by adding four volumes of absolute EtOH cooled in an ice bath. Crystals were dried in a vacuum desiccator over P2O5. [Donovan and Kegeles JACS 83 255 7967]. 

If placed in water and adjusted to a pH of 7, will the following migrate toward the anode or the cathode if placed in an electrical field (a) Aspartic acid, (b) alanine, (c) tyrosine, (d) lysine, (e) arginine, and (f) glutamine... 

ESR Spectral Data on Free Radicals and Browning in the Reaction of Sugars and Other Carbonyl Compounds with a- or B-Alanine ... 

Human blood samples Myocardial infarction 36 MS-based metabolite profiling platform B Alanine, aminoisobutyric acid, hypoxanthine, isoleucine/leucine, malonic (15)... 

Fig. 3. Reactions catalyzed by (a) aspartate transaminase and (b) alanine transaminase.

B) percent b-alanine plus g-aminobutyric acid (%(BALA+GABA)) versus the vanillic acid vanillin ratio (Ad/Al)v. Symbols are as in Fig. 15.13. 

Figure 9.9 Assigning configu- ia) ration to (a) ( j-glyceraldehyde and (b) ( + )-alanine. Both happen to have the S configuration, although one is levorotatory and the other is dextrorotatory.

Dado, G. P. and Gellman, S. H., Intramolecular hydrogen bonding in derivatives of B-alanine and y-amino butyric acid Model studies for the folding of unnatural polypeptide backbones, J. Am. Chem. Soc. 116, 1054-1062 (1994). 

Devise a synthesis of each amino acid from acetaldehyde (CH3CHO) (a) glycine (b) alanine. 

Pantothenic acid is formed from b-alanine and pantoic acid. 

Lincomycin hydrochloride and aminoglycoside hydrochloride were determined in pharmaceuticals by Isotachophoresis. In this method, a mixture of 0.02 M potassium acetate and 0.3 % hydroxypropylmethyl cellulose (15,000) was used as an aqueous electrolyte system, whereas a mixture of 20um 1,4-aminobutyric acid in acetic acid (pH 4.72) or 0.02 M glycylglycine or B -alanine was used as the terminator. The analysis was performed at a constant current of 200 jjA at 5°C. it was found that the minimum amount that could be quantitated by this method was 1.6 nmol and the relative standard deviation was 2%. 

Figure 38 Peptide nucleic acid backbones (a) glycine-ethylenediamine, (b) / -alanine-ethylenediamine and (c) glycine-propylene diamine. All have bases (B) linked by acetyl groups, except for (d) which has a propionyl linker...

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