Azurophil granules

Myeloperoxidase resides in a vesicle in the neutrophil called the azurophilic granule. This vesicle fuses with the phagocytic vesicle, which contains the bacte-rium exposing the bacterium to the enzyme as well as to its toxic product. 

In order to function efficiently, myeloperoxidase must be translocated from its intracellular location, the azurophilic granule, to the site of NADPH oxi- 

The antimicrobial neutrophil proteins are located within intracellular granules. Approximately 30% of all neutrophil granules contain myeloperoxidase, and these azurophilic granules are the first granule types to be 

R4. Ransom, J. T., and Reeves, J. P., Accumulation of amino acids within intracellular lysosomes of rat polymorphonuclear leukocytes incubated with amino acid methyl esters. Evidence for the internal acidification of azurophilic granules. J. Biol. Chem. 258, 9270-9275 (1983). 

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