2- azoles, synthesis

Benzimidazolo[l,2-c]thiatri azoles synthesis, 6, 612 Benz[cd]indazole antiaromaticity, 5, 208 Benz[cd]indazole, dihydroaromaticity, 5, 208 Benz[e]indolizine synthesis, 4, 466 Benzipiperylon biological activity, 5, 296 Benz[/]isoindoles synthesis, 4, 266... 

H-Benzo[a]carbazole, 4,4a,5,l 1,1 la,l Ib-hexahydro-synthesis, 4, 283 Benzo[b]carbazole, N-acetyl-photochemical rearrangements, 4, 204 Benzo[/]chroman-4-one, 9-hydroxy-2,2-dimethyl-synthesis, 3, 851 Benzochromanones synthesis, 3, 850, 851, 855 Benzochromones synthesis, 3, 821 Benzocinnoline-N-imide ring expansion, 7, 255 Benzocinnolines synthesis, 2, 69, 75 UV, 2, 127 Benzocoumarins synthesis, 3, 810 Benzo[15]crown-5 potassium complex crystal stmcture, 7, 735 sodium complex crystal stmcture, 7, 735 Benzo[ 18]cr own-6 membrane transport and, 7, 756 Benzo[b]cyclohepta[d]furans synthesis, 4, 106 Benzocycloheptathi azoles synthesis, 5, 120... 

Only 2,3-dihydropyrrolo[2,l-3]thiazoles have been described. When refluxing in POCl3, compounds 378 were found to give pyrrolo[2,l-b]thiazole derivatives 379 in good yields. Formally, this reaction is like a Chichibabin pyrrolothi-azole synthesis however, in contrast with the basic conditions used in the typical procedure, acidic conditions were employed in the present case (Equation 66) <2004S2317>. 

Wipf, P. Venkatraman, S. An Improved Protocol for Azole Synthesis with PEG-Supported Burgess Reagent, Tetrahedron Lett. 1996, 37, 4659. 

Thieno[2,3 -6]selenophenes lithiation, 4, 950 Thienospirans synthesis, 4, 760 Thieno[3,4-c][l,2,5]thiadiazoles cycloaddition reactions, 6, 534 reactions, 6, 1036 synthesis, 6, 1042, 1044 Thieno[2,3-d]thiazole, 2-acylamino-synthesis, 6, 1010 Thieno[2,3-d]thiazoles synthesis, 5, 116 6, 988, 994 Thieno[3,2-d]thi azoles synthesis, 5, 135 6, 1015 Thieno[3,4-d]thiazolidine-2-thione, perhydro-... 

Wagner-Wysiecka, E. Luboch, E. Kowalczyk, M. and Biemat, J.F. (2003) Chromogenic macrocyclic derivatives of azoles - synthesis and properties, Tetrahedron 59, 4415 - 4420. 

Upadhayaya, R. S., Sinha, N., Jain, S., Kishore, N., Chandra, R., Arora, S.K. Optically active antifungal azoles synthesis and antifungal activity of (2R,3S)-2-(2,4-difluorophenyl)-3-(5-[2-[4-arylpipera-zin-l-yl]ethyl]tetrazol-2-yl/l-yl)-l-[ 1,2,4]-triazol-l-yl-butan-2-ol. Bioorg. Med. Chem. 2004, 12, 2225-2238. 

Azoles, synthesis using trimethylsilyldiazomethane as C—N=N synthon 86YGK149. 

Pyrano[3,2-g]benzoxazine, dihydrosynthesis, 3, 714 Pyranobenzoxazines synthesis, 6, 190 Pyranobenzoxazoles mass spectra, 3, 615 Py rano[2,3- a]carb azoles synthesis, 4, 235 Pyrano[2,3-fe]carbazoles synthesis, 4, 235 Pyrano[3,2-a]carbazoles synthesis, 4, 235 Pyranochromones synthesis, 3, 821 Pyranochromones, dihydrosynthesis, 3, 816-817 Pyranocoumarins crystal data, 3, 623 mass spectra, 3, 610 Pyranodipyranones synthesis, 3, 794 Pyrano[3,2-fe]indol-4-ones synthesis, 4, 302 Pyran-2-ol, dihydrodehydration, 3, 762 Pyran-2-ol, 3-methyltetrahydro-synthesis, 3, 775 Pyran-2-ol, tetrahydro-6-substituted synthesis, 3, 775 Pyran-4-ol, tetrahydro-IR spectra, 3, 594 Raman spectra, 3, 594 Pyranols, tetrahydro-bond lengths, 3, 621 synthesis, 3, 777... 

One of the best known applications of the Knorr pj azole synthesis in drug discovery is the synthesis of celecoxib (Celebrex), a selective COX-2 inhibitor prescribed as an analgesic. As shown below, the substrate dione 26 was prepared by the Claisen condensation of 4-methylacetophenone 24 with ethyl trifluoroacetate 25 in the presence of NaOMe in methanol under reflux. Subsequent diarylpyrazole formation from the condensation of dione and 4-sulfonamidophenylhydrazine hydrochloride then delivered celecoxib 27. ... 

Imidazo[ 1,2-e]thiazoles biological activity, 6, 1024 reactions, 6, 1041 synthesis, 6, 1048 Imidazo[2, l-6]thiazoles electrophilic substitution, 6, 979 synthesis, 6, 992, 993, 1010, 1018 Imidazo[3,l-6]thiazoles synthesis, 6, 986 Imidazo[5,l-6]thi azoles biological activity, 6, 1024 synthesis, 6, 1017 Imidazo[2,l-6]thiazolium chloride synthesis, 6, 1013... 

Pyrimido[4,5-6]quinolinium salts pseudo bases - ring opening, 3, 208 Pyrimido[4,5-6]quinolinium salts, 4-chloro-hydrolysis, 3, 214 Pyrimido[4,5-6]quinolinones synthesis, 3, 228 Pyrimido[4,5 -6]quinolin-5-ones synthesis, 3, 221-222 Pyrimidothiadi azoles reactions, 6, 533 Pyrimidothiazines synthesis, 4, 527 Pyrimidothiazinones mass spectra, 2, 23... 

Thiazolo[5,4-d]thiazole,2,5-diphenyl-synthesis, 6, 1022 Thiazolo[5,4-[Pg.878]

A one-step synthesis o( mtnles from carbonyls by a reductive cyanation with tosylmethyl isocyanide (TosMIC), also synthesis of 1,3-azole or of ketones... 

Tolylaulfonylmethyl isocyanide is a useful and versatile reagent in organic chemistry. It has been used for the synthesis of several azole ring systems by base-induced addition of its C—N=C moiety to various... 

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