Examples of Notable Syntheses Involving 1,3-Azoles

4(5)-Fluorohistamine was synthesised via nucleophilic displacement of a side-chain leaving group (cf. pyrroles, 16.11). [Pg.478]

The synthesis of thieno[2,3- f]imidazole illustrates again the selectivity in halogen-metal exchange processes in imidazoles, hi this sequence a vinyl was used as A-protecting group, and it includes a nucleophilic displacement of bromine from the 4-position, activated by the 5-aldehyde. [Pg.478]

3 Inhibitor of Transforming Growth Factor f3l, Type 1 Receptor [Pg.478]

This sequence illustrates the interaction of an amidine and a 2-bromo-ketone with subsequent ring haloge-nation and palladium-catalysed coupling. [Pg.478]

Draw structures for the intermediates and final products that are formed when (i) 4-phenyloxazole is heated with but-l-yn-3-one C6Hg02 (ii) 5-ethoxy oxazole is heated with dimethyl acetylenedicarboxylate CioHi20g. [Pg.479]

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