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Azoles Antihistamines

Drugs that may affect nelfinavir include anticonvulsants, azithromycin, azole antifungals, efavirenz, delavirdine, HMG-CoA reductase inhibitors, indinavir, interleukins, nevirapine, rifabutin, rifampin, ritonavir, saquinavir, St. John s wort. Drugs that may be affected by nelfinavir include amiodarone, antiarrhythmics (amiodarone, quinidine), azithromycin, benzodiazepines, efavirenz, ergot alkaloids, delavirdine, didanosine, fentanyl, indinavir, lamivudine methadone, nonsedating antihistamines, oral contraceptives, phenytoin, pimozide, quinidine, rifabutin, saquinavir, sildenafil, sirolimus, tacrolimus, zidovudine. [Pg.1820]

Diazepam (Valium, Diastat) [C-IVj [Anxiolytic, Skeletal Muscle Relaxant, Anticonvulsant, Sedative/Hypnotic/ Benzodiazepine] Uses Anxiety, EtOH withdrawal, muscle spasm, status epilepticus, panic disorders, amnesia, preprocedure sedation Action Benzodiazepine Dose Adults. Status epilepticus 5-10 mg IV/IM Anxiety 2-5 mg IM/IV Preprocedure 5-10 mg IV just prior to procedure Peds. Status epilepticus 0.5-2 mg IV/IM Sedation 0.2-0.5 mg/kg IV (onset w/in 5IV and 30 min IM duration about 1 h IV and IM) Caution [D, / -] Contra Coma, CNS depression, resp d es-sion, NAG, severe uncontrolled pain, PRG Disp Tabs 2, 5, 10 mg soln 1, 5 mg/mL inj 5 mg/mL rectal gel 2.5, 5, 10, 20 mg/mL SE Sedation, amnesia, bradycardia, i BP, rash, X resp rate Interactions T Effects W/ antihistamines, azole antifungals, BBs, CNS depressants, cimetidine, ciprofloxin, disulfiram, INH, OCP, omeprazole, phenytoin, valproic acid, verapamil, EtOH, kava kava, valman T effects OF digoxin, diuretics X effects w/ barbiturates, carbamazepine. [Pg.13]

Quazepam (Doral) [C IV] [Sedative/Hypnotic/ Benzodiazepine] Uses Insomnia Action Benzodiazepine Dose 7.5-15 mg PO hs PRN i in elderly hqjatic failure Caution [X, /-] NA glaucoma Contra PRG, sleep apnea Disp Tabs SE Sedation, hangovCT, somnolence, resp depression Interactions T Effects W/ azole antifungals, cimetidine, digoxin, disulfiram, INH, levodopa, macrolides, neuroleptics, phenytoin, quinolones, SSRIs, verapamil, grapefruit juice, EtOH effects W/carbamazepine, rifampin, rifabutin, tobacco EMS Use caution w/ other benzodiazepines, antihistamines, opioids and verapamil, can T CNS depression concurrent EtOH and grapefruit juice use T CNS depression OD May cause profound CNS depression, confusion, bradycardia, hypotension, and altered reflexes flumazenil can be used as antidote activated charcoal may be effective... [Pg.269]

Several reports on the application of the intermolecular arylation of primary alkylamines have appeared. For example, the reaction of primary amines with chloro 1,3 azoles has been used to produce the H-l-antihistaminic norastemizole [153]. As shown in Eq. (32), the palladium chemistry is dictated by the steric properties of the amines. This property creates selectivity that complements the thermal chemistry, which is dictated by amine nucleophilicity. These researchers have also shown that this high selectivity for arylation of primary over secondary amines with catalysts containing BINAP as ligand allows for the rapid assembly of other multiamino-based structures [154]. [Pg.230]

ANTIBIOTICS - macrolides (especially azithromycin, clarithromycin, parenteral erythromycin, telithromycin), quinupristin/ dalfbpristin 3. ANTICANCER AND IMMUNOMODULATING DRUGS - arsenic trioxide 4. ANTIDEPRESSANTS - TCAs, venlafaxine S. ANTIEMETICS-dolasetron 6. ANTIFUNGALS - fluconazole, posacon-azole, voriconazole 7. ANTIHISTAMINES-terfenadine, hydroxyzine, mizolastine... [Pg.526]

Clinically important, potentially hazardous interactions with antihistamines, azole antifungals, benzodiazepines, carbamazepine, cimetidine, delavirdine, diazepam, erythromycin, HIV protease inhibitors, ketorolac, macrolide antibiotics, neuroleptics, phenobarbital, phenytoin, rifampin, ritonavir... [Pg.81]

Toxicity Nausea, diarrhea, thrombocytopenia, hyperbilirubinemia, and nephrolithiasis occur. To reduce renal damage, it is important to maintain good hydration. Indinavir is a substrate for and an inhibitor of the cytochrome P450 isoform CYP3A4 and is implicated in drug interactions. Serum levels of indinavir are increased by azole antifungals and decreased by rifamycins. Indinavir increases the serum levels of antihistamines, benzodiazepines, and rifampin. [Pg.432]

In the presence of CYP3A4 inhibitors such as azole antifungal drugs, erythromycin and grapefruit juice, blood concentrations of the antihistamine terfenadine significantly increase, resulting in cardiotoxicity. Terfenadine has been withdrawn from sale in the US. [Pg.333]

Fluconazole, ketoconazole and voriconazole have been associated with prolongation of the QT interval, although generally not to a clinically relevant extent. However, they may also raise the levels of other drugs that prolong the QT interval, and these combinations are often contraindicated, see Antihistamines + Azoles , p.584. [Pg.207]

The effect of various azole antifungals on the plasma levels of the non-sedating antihistamines, and their cardiac effects from controlled studies are summarised in Table 15.3 , (p.585). The subsections below include data from case reports and further studies. [Pg.584]

Table 15.3 Summary of the effects of azoles on the pharmacokinetics and cardiovascular effects of non-sedating antihistamines... Table 15.3 Summary of the effects of azoles on the pharmacokinetics and cardiovascular effects of non-sedating antihistamines...
Antihistamine (Oral unless specified) Azole (Oral unless specified) Duration of combined use (days) Subjects Cmax increase AUC increase Effect on QTc ... [Pg.585]


See other pages where Azoles Antihistamines is mentioned: [Pg.570]    [Pg.647]    [Pg.570]    [Pg.647]    [Pg.142]    [Pg.1808]    [Pg.1816]    [Pg.24]    [Pg.131]    [Pg.135]    [Pg.286]    [Pg.312]    [Pg.22]    [Pg.131]    [Pg.135]    [Pg.170]    [Pg.286]    [Pg.296]    [Pg.312]    [Pg.661]    [Pg.78]    [Pg.159]    [Pg.131]    [Pg.269]    [Pg.296]    [Pg.312]    [Pg.738]    [Pg.582]    [Pg.584]    [Pg.587]    [Pg.587]    [Pg.594]   
See also in sourсe #XX -- [ Pg.584 ]




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