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Antihistamines terfenadine

One can find many more examples where a subtle modification in a side chain leads to a new drug that produces a drastically different therapeutic or toxicological outcome. This is clearly illustrated by the nonsedating antihistamine terfenadine (Seldane), which produces cardiotoxicity when given with certain drugs that inhibits its metabolism. This product is no longer marketed. It has been replaced by its safer but no less effective carboxylic oxidative metabolite fexofenadine (Allegra). [Pg.9]

P155) (114) arrhythmias. Induced by drugs including antiarrhythmics (quinidine), antipsychotics (chlorpromazine), psychotropics (tricylic antidepressants), macrolide antibiotics (clathromycin), HI antihistamines (terfenadine, astemizole) (113) deletions mutations create defective ion channel receptors (115)... [Pg.79]

Q7 Fexofenadine is a metabolite of another antihistamine, terfenadine, but has little or no cardiac toxicity. The development of sedation and antimuscarinic effects are limited since fexofenadine cannot easily cross the blood-brain barrier (only a very small amount can cross this barrier). The recommended adult dosage is 120 mg once daily. It is also recommended for children above 12 years of age. [Pg.202]

FLECAINIDE ANTIHISTAMINES-TERFENADINE, HYDROXYZINE, MIZOLASTINE Risk of arrhythmias Additive effect Avoid co-administration... [Pg.20]

ANTIHISTAMINES-terfenadine, hydroxyzine, mizolastine 8. ANTI-M ALARIALS - artemether with lumefantrine, chloroquine, hydroxychloroquine, mefloquine, quinine... [Pg.26]

PROPAFENONE I. ANTIARRHYTHMICS - disopyra-mide, procainamide 2. ANTIBIOTICS - macrolides (especially azithromycin, clarithromycin, parenteral erythromycin, telithromycin), quinolones (especially moxifloxacin), quinupristin/ dalfopristin 3. ANTICANCER AND IMMUNOMODULATING DRUGS -arsenic trioxide 4. ANTIDEPRESSANTS - TCAs, venlafaxine 5. ANTIEMETICS-dolasetron 6. ANTIFUNGALS-fluconazole, posaconazole, voriconazole 7. ANTIHISTAMINES - terfenadine, hydroxyzine, mizolastine 8. ANTI-M ALARIALS - artemether with lumefantrine, chloroquine, hydroxychloroquine, mefloquine, quinine 9. ANTIPROTOZOALS - pentamidine isetionate 10. ANTIPSYCHOTICS-atypicals, phenothiazines, pimozide II. BETA-BLOCKERS - sotalol 12. BRONCHODILATORS -parenteral bronchodilators 13. CNS STIMULANTS - atomoxetine Risk of ventricular arrhythmias, particularly torsades de pointes Additive effect these drugs prolong the Q-T interval. Also, amitriptyline, clomipramine and desipramine levels may be t by propafenone. Amitriptyline and clomipramine may t propafenone levels. Propafenone and these TCAs inhibit CYP2D6-mediated metabolism of each other Avoid co-administration... [Pg.29]

ANTIBIOTICS-macrolides (especially azithromycin, clarithromycin, parenteral erythromycin, telithromycin), quinolones (especially moxifloxacin), quinupristin/ dalfbpristin 3. ANTIDEPRESSANTS - TCAs, venlafaxine 4. ANTI EMETICS -dolasetron 5. ANTIFUNGALS-fluconazole, posaconazole, voriconazole 6. ANTIHISTAMINES - terfenadine, hydroxyzine, mizolastine... [Pg.251]

Antihistamines terfenadine (Seldane) astemizole (Hismanol) loratadine (Claritin) diphenhydramine (Benadryl)... [Pg.444]

Figure 3 Promiscuous HERG channels are blocked by structurally diverse molecules [from (122)]. In addition to compounds developed for K+ channel blockade (Dofetilide and Sotalol), a wide range of compounds, from antihistamines (Terfenadine) to antibiotics (Erythromycin), block HERG as an adverse side effect. Figure 3 Promiscuous HERG channels are blocked by structurally diverse molecules [from (122)]. In addition to compounds developed for K+ channel blockade (Dofetilide and Sotalol), a wide range of compounds, from antihistamines (Terfenadine) to antibiotics (Erythromycin), block HERG as an adverse side effect.
Roy M, Dumaine R, Brown AM. HERG, a primary human ventricular target of the nonsedating antihistamine terfenadine. Circulation 1996 94 817-23. [Pg.461]

Unlike other antihistamines, terfenadine has minimal anticholinergic activity and does not potentiate the CNS effects of alcohol, antianxiety agents, or other CNS depressants. [Pg.678]

Reports of cardiac arrhythmias caused by unusually high blood levels of two antihistamines, terfenadine and astemizole, led to their removal from the market. These effects were best explained by... [Pg.37]

ANTIEMETICS - dolasetron 6. ANTI-FUNGALS - fluconazole, posaconazole, voriconazole 7. ANTIHISTAMINES-terfenadine, hydroxyzine, mizolastine... [Pg.86]

ANTIDEPRESSANTS - TCAs, venlafaxine 5. ANTIEMETICS-dolasetron 6. ANTIFUNGALS-fluconazole, posaconazole, voriconazole 7. ANTIHISTAMINES-terfenadine, hydroxyzine, mizolas-tine 8. ANTIMALARIALS -artemether with lumefantrine, chloroquine, hydroxychloroquine, mefloquine, quinine 9. ANTIPRO-TOZOALS - pentamidine isetionate... [Pg.92]

See other pages where Antihistamines terfenadine is mentioned: [Pg.171]    [Pg.43]    [Pg.620]    [Pg.711]    [Pg.9]    [Pg.15]    [Pg.180]    [Pg.207]    [Pg.594]    [Pg.658]    [Pg.1020]    [Pg.64]    [Pg.161]    [Pg.173]    [Pg.83]    [Pg.348]    [Pg.394]    [Pg.48]   
See also in sourсe #XX -- [ Pg.78 ]



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