Azocinone

Azocin-2( 1H )-one, hexahydro- 1-phenyl-photochemical rearrangement, 7, 656 Azodn-2( 1H )-one, 1,2,7,8-tetrahydro-synthesis, 7, 662 Azocin-5-one IR spectra, 7, 16 transannular interactions, 7, 14 Azocin-5-one, l-(2,4-dimethylphenyl)-IR spectrum, 7, 657 Azocin-5-one, methoxycarbonyl-synthesis, 7, 657 Azocin-5-one, 1-methyl-IR spectrum, 7, 657 synthesis, 7, 657 Azodn-5-one, 1-p-tolyl-IR spectrum, 7, 657 Azocinones... 

Tire tautomeric equilibrium of azocinones 65 has been studied by NMR, IR, and UV spectroscopy (90JHC1323). Dioxo derivatives of diazocines all exist as such, as illustrated by the analgetic 66 (75MI37) and the extensively studied dibenzo[h,/][l,4]diazocines (67) [81JCS(P1)988]. 

Unsaturated azocinones were synthesized by 2 -i- 2 cycloaddition of benzoni-triles to phenols and a final radical mediated fragmentation [67]. 

The mitomycins (331) have attracted much attention as a result of their interesting structure and especially because of their potent anti-cancer properties [102]. One approach to these materials is illustrated in Scheme 22 [103]. A key intermediate in the implementation of this plan is azocinone 333, a substance... 

Azocinones are in thermal equilibrium with 8-azabicyclo[4.2.0]octa-3,5-dienones, as measured by NMR (Section 5.19.2.3). 

Benz-, dibenz- and tribenz-azocinones are readily obtained by Beckmann rearrangement of the corresponding benzotropone oximes. The highly substituted 1H- 2- benzazocine (115a) is produced in an electrocyclic reaction when the ketone (115) is heated in toluene... 

Azabicyclo[4.2.0]octan-l-ols were converted to azocinone derivatives 4 and 5 on photolysis in the presence of an excess of red mercury(II) oxide and iodine.189 A similar ring enlargement is reported for 2-azabicyclo[4.2.0]octan-6-ol to give 6.190... 

The mode of antitumor action of 60 is activated in vivo by bioreduction of the hydroxylamine moiety (Scheme 9) leading to the ring-expanded product, azocinone 61, which upon cyclization furnishes the mitosene-like 62 <1997T10229>. 

Calculations of the interactions between matured catalytic antibody AZ28 and the different conformers and enantiomers of 2,5-diaryl-hexa-l,5-dien-3-ol, allowing for the flexibility of the antibody, have reproduced, qualitatively only, the observed selectivity of the antibody for the S,equatorial substrate.7 Doubly a,/9-unsaturated A-arylimines (3) have been shown to react with a,j3-unsaturated ketenes to give azocinones (4),... 

Further investigation of the Okinawan sponge Haliclona sp. resulted in the isolation of manzamines B-F (182-186), which show cytotoxic activity (152-154). The structures of manzamines B (182) and C (183) were based on X-ray analysis. Manzamine F (186) was found to be identical with keramamine B, the structure of which with a 1,2,3-triazacyclohexane moiety (181) was revised to structure 186 containing a hexahydro-5(2//)-azocinone ring. Total synthesis of manzamine C (183) was achieved by the... 

The procedure described is a one-step conversion of cycloheptanone into hexahydro-2(lH)-azocinone. The method is general and is characterized by good yields, mild conditions, and easy preparation of the product in pure form from readily available starting materials. Several methods are described in the patent literature for simultaneous oximation of ketones and rearrangement to the corresponding oxime, Including the use of hydroxylamine and sulfuric... 

Hexahydro-2(lH)-azocinone 2(lH)-Azocinone, hexahydro- (9) (673-66-5) Hydroxylamine-O-sulfonic acid (8,9) (2950-43-8)... 

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