Axotomy, peripheral

Zigmond RE, Hyatt-Sachs H, Mohney RP, Schreiber RC, Shadiack AM, Sun Y, Vaccariello SA (1996) Changes in neuropeptide phenotype after axotomy of adult peripheral neurons and the role of leukemia inhibitory... 

Barron, K. D., Marciano, F. F., Amundson, R., and Mankes, R., Perineuronal glial responses after axotomy of central and peripheral axons. A comparison, Brain Res., 523,219, 1990. 

Emfors, P, Rosario, C. M., Merlio, J. P., Grant, G., Aldskogius, H., and Persson, H., Expression of mRNAs for neurotrophin receptors in the dorsal root ganglion and spinal cord during development and following peripheral or central axotomy, Mol. Brain Res., 17,217, 1993. 

Burchiel KJ 1984 Effects of electrical and mechanical stimulation on two foci of spontaneous activity which develop in primary afferent neurons after peripheral axotomy. Pain 18 249—265... 

Dib-Hajj SD, Tyrrell L, Black J A, Waxman SG 1998a NaN, a novel voltage-gated Na channel preferentially expressed in peripheral sensory neurons and down-regulated after axotomy. Proc Natl Acad Sci USA 95 8963-8968... 

Peripheral axotomy caused a decrease of Y1 mRNA in the small neurons and an increase in large neurons. These results suggested that the DRG Y1 receptor is mosdy a prejunctional receptor in primary afferent neurons and that it may play a role in the modulation of somatosensory information (Zhang et al., 1994). Low levels of Y1 mRNA have also been reported for rat splenic lymphocytes as documented by a partial cDNA clone, PCR and RNase protection (Petitto et al., 1994). A developmental study by in situ hybridization of whole rat embryo sections (Jazin et al., 1993) detected the earliest Y1 mRNA around day 14, both in diencephalon and spinal cord. 

Zhang, X., Wiesenfeld-Hallin, Z. Hokfelt, T. (1994) Effect of peripheral axotomy on expression of neuropeptide Y receptor mRNA in rat lumbar dorsal root ganglia. Eur. J. Neurosci. 6, 43-57. 

Evidence, albeit indirect, for hemopexin receptor expression on ganglia comes from recent studies in rat adrenal phaechromocytoma (PC 12) cells in which HO-1 and MT-1 mRNA levels are induced upon incubation with heme-hemopexin (Figure 5-3). Heme-hemopexin can replace iron-transferrin as the sole source of nutrient iron and in activating protein kinase C providing evidence that hemopexin is potentially important in the regulation of cell growth under certain circumstances. When peripheral nerves are injured, e.g. axotomy of the sciatic nerve, he-... 

Verge, V. M., Xu, Z., Xu, X. J., Wiesenfeld-Hallin, Z., and Hokfelt, T. (1992). Marked increase in nitric oxide synthase mRNA in rat dorsal root ganglia after peripheral axotomy In situ hybridization and functional studies. Proc. Natl. Acad. Sci. U.S.A. 89,11617-11621. 

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