Available Chemicals Directory ACD

Auxotrophic plant pathogens, 13 350-351 Available Chemicals Directory (ACD), 6 19-20... 

Most prediction tools for druglikeness use the MDL Available Chemicals Directory (ACD) [89] as a list of nondrugs and one of three databases as a list of drugs MDL Drug Data Report (MDDR) [89], MDL Comprehensive Medicinal Chemistry (CMC) [89], or Derwent World Drug Index (WDI) [90]. 

Many commercial vendors and academic labs provide collection of compounds or fragments (Sigma-Aldrige, Available Chemicals Directory (ACD) (http //www.symyx.com), Maybridge (www.maybridge.com), TCI America (http //www. tciamerica.com), ChemDB (51) (http //cdb.ics.uci.edu), ZINC... 

There exist a multitude of chemical reagent sources. The Available Chemical Directory (ACD) collection, from Symyx Technologies Inc., lists as many as 1,160,000 unique chemicals with chemical structure, pricing, supplier, purity, forms, etc. 

Available Chemicals Directory (ACD) Documentation, Version 95.2, MDL Information Systems, Inc., 1995. 

Available Chemicals Directory (ACD, ACD screen) MDL 171 http //www.mdli.com... 

Available Chemicals Directory (ACD) is available from MDL Information Systems Inc., San... 

Synthetic chemical structures were obtained from the Available Chemicals Directory (ACD, MDL Information Systems Inc., San Leardo, CA, n 182 822) and a representative pool of test substances from the Synthetics database (Bayer AG, n not reported). 

The 3-point and 4-point pharmacophore methods can be used to analyse and compare different sets of compounds and databases. Figure 7 illustrates the 4-point pharmacophores for the MDDR database [25], the Available Chemical Directory (ACD) [25], a company registry database and a set of combinatorial libraries reported by Mason and co-workers [7, 11, 13]. Previous studies [3] had shown the increase in resolution possible using 4-point instead of 3-point pharmacophores. 

There is a wealth of databases that code available compounds typically in the two-dimensional standard data (2D-SD) format including connectivity from MACCS (32, 64). The most common databases are the Available Chemicals Directory (ACD) (42), Spresi (65), Chemical Abstracts Database (66), and the National Cancer Institute Database (67, 68). Many vendors of chemicals also provide searchable databases with 2D-structure and... 

The fine chemicals directory (FCD) and the available chemicals directory (ACD) are distributed by Molecular Design Ltd., San Leandro, 2132 FaraUon Drive, CA 94577... 

To access the usefulness of the developed model, the overall solubility for the compounds within the World Drug Index (WDI) [64] and the Available Chemical Directory (ACD) [63] databases were calculated. After filtering both databases with the same criteria as used for datasets A and B, the aqueous solubility of the remaining compounds were predicted. To... 

Another approach followed by Wang et al. led to an inhibitor of Tritrichomonas foetus hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRT). The X-ray structure of this enzyme is available and it was used in a search for novel scaffolds. The Available Chemicals Directory (ACD) was screened with the program DOCK. Isatin and phthalic anhydride were capable of mimicking the substrate purine base and acting as competitive inhibitors. A virtual library of substituted... 

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