Automated quantitative analysis

MacCoss MJ, Wu CC, Liu H, Sadygov R, Yates JR 3rd. A correlation algorithm for the automated quantitative analysis of shotgun proteomics data. Anal Chem 2003 75 6912-6921. 

A correlation algorithm for the automated quantitative analysis of shotgun proteomics data. Anal. Chem. 

High-throughput metabohc stability tests using hver microsomal preparations is one of the tools to speed up processes of lead optimization in early drug discovery. The extent of CYP metabolism of new chemical entities is investigated by fast, preferentially automated quantitative analysis of microsomal incubation samples. 

M. Hermansson, A. Uphoff, R. Kakela, P. Somerhaqu, Automated quantitative analysis of complex lipidomes by LC-MS, Anal. Chem., 77 (2005) 2166. 

Figure 4 Automated hind-limb movement apparatus, (a) The camera can register the movements of the dyed soles of the paws of the rat from below, (b) The wheel with a transparent front facing the axially mounted color TV camera. (Reproduced from Tanger HJ, Vanwersch RAP, and Wolthius OL (1984) Automated quantitative analysis of coordinated locomotor behaviour in rats. Journal of Neuroscience Methods 10 237-245, with permission from Elsevier.)... 

Sinner, M., Simatupang, M.H. and Dietrichs, H.H., 1975. Automated quantitative analysis of wood carbohydrates by borate complex ion exchange chromatography. Wood Sci. Technol., 9 307—322. 

Berger AJ, Camp RL, Divito KA, Kluger HM, Halaban R, Rimm DL. Automated quantitative analysis of HDM2 expression in malignant melanoma shows association with early-stage disease and improved outcome. Cancer Res 2004 64 8767-8772. 

Hermansson M, et al. Automated quantitative analysis of complex lipidomes by liquid... 

Correct identification of plaque types depends on their structure, composition and sufficient image resolution. Recent work in IVUS backscatter analysis demonstrates the capability of IVUS to characterize specific lesions and identify the kinds of plaques that lead to various clinical syndromes [25,26]. Other techniques, such as wavelet analysis and elastography [27], are being developed to identify plaque composition as well. These techniques have been used to identify plaque composition and geometry using IVUS. The advances in IVUS have allowed for automated quantitative analysis of vessel... 

Hermansson, M., Uphoff, A., Kakela, R., Somerharju, P. (2005) Automated quantitative analysis of complex hpidomes by liquid chromatography/mass spectrometry. Anal. Chem. 77, 2166-2175. 

Slouf et al. [37] reported a novel automated quantitative analysis technique, SEMq, which was based on a light scattering theory. In this method automated image analysis of electron micrographs is used to determine the total amount of wear particles released into the tissues around total joint replacements. This technique was shown to provide rapid, reliable, and reproducible results, which indicated that the distribution of wear particles around TJRs is nonhomogeneous [37]. However, this technique does not calculate absolute numbers of wear particles but rather determines relative numbers of wear particles in one sample compared to another. The technique may also be sensitive to errors introduced by particle cliunping and protein contamination of filters used for SEM analysis. 

---