Autoimmunity streptozotocin

Only a few drugs have been identified as being capable of inducing autoimmune phenomena in mice. Among these are D-penicillamine, quinidine, streptozotocin (an anti-neoplastic drug that is also used as a model compound to induce diabetes) and procainamide. 

Herold, K.C. et al., Regulation of cytokine production during development of autoimmune diabetes induced with multiple low doses of streptozotocin. J. Immunol., 156,3521,1996. 

Albers, R. et al., Selective immunomodulation by the autoimmunity-inducing xenobiotics streptozotocin and HgC12. Eur. J. Immunol., 28, 1233, 1998. 

Catalase from autoimmune and streptozotocin-induced diabetes Islets Protection from oxidative damage Benhamou et al. (1998)... 

Hotta, M., Tashiro, F., Ikegami, H., Niwa, H., Ogihara, T., Yodoi, J. and Miyazaki, J. (1998). Pancreatic beta cell-specific expression of thioredoxin, an antioxidative and antiapoptotic protein, prevents autoimmune and Streptozotocin-induced diabetes. J. Exp. Med. 188, 1445-1451. 

Diabetes mellitus (DM) is an increasingly common disease of sugar metabolism. Juvenile-onset diabetes, also known as Type I or insulin-dependent diabetes (IDDM), is an autoimmune disease that results in decreased release of insulin by the pancreas. Late-onset diabetes, also known as Type II or non-insulin-dependent diabetes (NIDDM), results from reduced sensitivity of cells to the insulin signal. A convenient animal model for studying diabetes and testing alternative therapies is the streptozotocin-freated diabetic rat. Streptozotocin (STZ) attacks the pancreas and decreases insulin production and release, thus, mimicking many aspects of the human disease. Since insulin is not orally absorbed, the oral administration of vanadium compounds that are insuhn-mimetic or insulin-enhancing would be a very attractive therapy ... 

Li X, Kaminski NE, Fischer LJ (2001) Examination of the immunosuppressive effect of delta-9-tetrahydrocannabinol in streptozotocin-induced autoimmune diabetes. Int Immunopharmacol 1 699-712... 

Song E-K, Hur H, Han M-K (2003) Epigallocatechin gallate prevents autoimmune diabetes induced by multiple low doses of streptozotocin in mice. Arch Pharm Res 26 559-563... 

Stosic-Gmjicic, S., Cvetkovic, I., Mangano, K., Hesta, M., Maksimovic-Ivanic, D., Harhaji, L., Popadic, D., Momdlovic, M., Miljkovic, D., Kim, J., Al-Abed, Y., and Nicoletti, F. (2007). A potent iimnunomodulatoiy compound, (S,R)-3-phenyl-4,5-dihydto-5-isoxazole acetic acid, prevents spontaneous and aceelerated forms of autoimmune diabetes in NOD mice and inhibits the iimnunoinllaiimiatory diabetes induced by multiple low doses of streptozotocin in CBA/H mice. J. Pharmacol. Exp. Ther. 320,1038-1049. 

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