Protecting from oxidative damage

PORRiNi M and Riso P (2000) Lymphocyte lycopene concentration and DNA protection from oxidative damage is increased in women after a short period of tomato consumption. JNutr 130(2) 189-92. 

Catalase from autoimmune and streptozotocin-induced diabetes Islets Protection from oxidative damage Benhamou et al. (1998)... 

The cytosolic compartment in mammalian cells is protected from oxidative damage caused by H2O2, by catalase and by the selenoenzyme glutathione peroxidase (GSHPx) GSHPx is also present in the mitochondria of all mammalian cells. 

Aminosalicylate oxidation by activated leukocytes and protection of cultured cells from oxidative damage. Biochem. Pharm. 36, 2467-2472. 

Moreover, carotenoids may quench electronically excited states and scavenge free radicals formed in the retina, and therefore protect biomolecules from oxidative damage. Due to the low energy level of the first excited triplet state ( Car), carotenoids (Car) can act as efficient acceptors of triplet state energy from photosensitizers (S) (Equation 15.1), such as all-tra .s-retinal, the photosensitizers of lipofuscin (Rozanowska et al., 1998), or singlet oxygen C02) (Equation 15.2) (Cantrell et al., 2003) ... 

Vitamin (a-tocopherol) is an antioxidant. As a lipid-soluble compound, it is especially important for protecting other lipids from oxidative damage. 

Although the acute vasodilator effects, as shown in in vitro studies (see above), may participate in the antihypertensive effects, the reduced blood pressure persisted even 42-48 h after the last administration of quercetin, when the plasma quercetin concentration and its metabolites fell bellow 25% of the peak post-administration levels [43]. Furthermore, the antihypertensive effects of quercetin did not appear to be related to its antioxidant properties since quercetin did not lower the urinary isoprostane F20 excretion, a prostaglandin-like compound produced in a non enzymatic reaction of arachidonic acid in membrane lipids and superoxide, which is currently used as a reliable marker of oxidative stress. The mechanisms involved in the antihypertensive effects and protection from organ damage... 

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