Attenuation of Renal Oxidative Stress with Garlic Oil

ATTENUATION OF RENAL OXIDATIVE STRESS WITH GARLIC OIL 

Nitrilotriacetic acid (NTA) is a constituent of various domestic and hospital detergents and is a common water contaminant. NTA forms water-soluble chelate complexes with various metal ions, including iron, at neutral pH. Its iron complex, Fe-NTA, is a known potent nephrotoxic agent. The renal toxicity is assumed to be caused by the elevation of serum free-iron concentration following the reduction of Fe-NTA at the luminal side of the proximal tubule, which generates reactive oxygen species and leads to enhancement of lipid peroxidation. 

The exact mechanism by which garlic oil may suppress Fe-NTA-mediated renal damage is not known. However, onion and garlic extracts have been shown to inhibit platelet aggregation and prostaglandin synthesis. 

AMELIORATION OF HYPERLIPIDEMIA IN CHRONIC AMI NONUCLEOSIDE NEPHROSIS BY GARLIC 

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