Atropine pharmacological action

This view was supported by the observation that choline on treatment with nitric acid yielded a product having a pharmacological action similar to that of muscarine as known up to that time. Comparison of the natural and artificial products by Bohm showed that the former was much more active than the latter and that its action was antagonised by atropine, whilst the artificial muscarine had a curare-like action on the atropinised frog. Later, Nothnagel investigated the action of... 

Pharmacological actions of atropine are due to equal blockade of M, and M3 muscarinic receptors. 

Constriction of the pupils is seen with virtually all opioid agonists. Miosis is a pharmacologic action to which little or no tolerance develops (Table 31-3) thus, it is valuable in the diagnosis of opioid overdose. Even in highly tolerant addicts, miosis is seen. This action, which can be blocked by opioid antagonists, is mediated by parasympathetic pathways, which, in turn, can be blocked by atropine. 

Pharmacological - actions at the same site. This is the typical agonist-antagonist competition for the same receptor. Atropine blocks the binding of acetylcholine. Naloxone blocks the binding of morphine. 

Which ONE of the following drugs most closely resembles atropine in its pharmacologic actions ... 

Q3 Patients who suffer a cardiac arrest are usually given epinephrine (adrenaline) and external cardiac massage. If necessary, atropine is also administered. Explain the pharmacological actions of epinephrine and atropine on the heart. 

Vojvodic, V. and Milosevic, M., Some pharmacological actions of oximes and atropine on the cadiovascular effects produced by pinacolyl methylphosphonofluoridate (soman) in rats, lugosl. Physiol. Pharmacol. Acta, 7, 439, 1971. 

Aminoalcohol esters, having the following general formula, have emerged from the outstanding pharmacological actions displayed by atropine ... 

In pharmacological experiments, remarkable antitussive action was shown for verticine and fritillarine, and hypotension and respiratory movement center paralytic actions were reported for peiminoside. It was reported that the alkaloid fraction showed atropine-like action, including a bronchial smooth-muscle relaxation effect and a mydriatic effect on the pupils [11,14]. 

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