Atropine ophthalmic ointment

Atropine Sulphate ophthalmic ointment Atropine Sulphate ophthalmic solution Atropine Sulphate tablets Glass, 1.8 M x 2mm I.D. 3% G3 /SlAB Nitrogen 225 FID Homatropine Hydrobromide USP (24, p. 179) USP (24, p. 179)... 

Atropine sulfate Atropine Sulfate Ophthalmic (Various) Ointment 1... 

TTie ability of certain drugs to cross the ocular and nasolacrimal epithelium means that these drugs are to some extent absorbed systemically. The degree to which this occurs in the horse has not been investigated extensively. However, topical atropine has been recognized as causing transient ileus, particularly in foals, and has been implicated in a very small number of fatal colic cases in adult horses (Brooks 1999). Dexametha-sone has been detected in the serum of horses 24 h after cessation of administration of a 0.1% ointment three times a day (Speiss et al 1999) and trainers of competition horses should be made aware of the possibility of forensic detection of topically administered ophthalmic drugs. 

Sample preparation Iiyections and ophthalmic solutions. Dilute with water to an atropine concentration of 80 p.g/mL, iiyect a 20 p,L aliquot. Ointment. Weigh out ointment equivalent to about 4 mg atropine sulfate, add 10 mL THF water 80 20, sonicate and swirl until the ointment is completely dispersed, make up to 50 mL with water, filter (0.45 p,m), inject a 20 p,L aliquot... 

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