Atrazine registrations

APVMA (October 2004). The reconsideration of approvals of the active constituent atrazine, registrations of products containing atrazine, and their associated labels. 

APVMA (2004). The Reconsideration of Approvals of the Active Constituent Atrazine, Registrations of Products Containing Atrazine and Their Associated Labels, October. APVMA. 

APVMA (formerly the National Registrations Authority for Agricultural and Veterinary Chemicals) (November 1997). The NRA review of atrazine. 

National Registration Authority for Agriculture and Veterinary Chemicals of Australia (November 1999). The NRA review of atrazine existing chemical review program. 

With the approval of simazine in 1957 by the USFDA, USDA, and USEPA, the basis and procedures for successful introductions of other chlorotriazines were established. Although additional development work was necessary for approval and registration of the subsequent chlorotriazines, the procedures to optimize the production, formulation, and directions for use and the protocols to analyze and understand metabolism and toxicology remained similar. Approval for the first commercial uses of simazine and atrazine in various countries are given in Tables 3.3 and 3.4, respectively. 

Regulatory bodies in the United States, the European Union, Australia, and France, as well as the World Health Organization, have all given atrazine favorable safety reviews for continued registration. The safe use and resulting benefits of the triazines in worldwide agricultural production are critical as farmers continue to feed our growing population. 

Soon after its initial registration, atrazine became a widely used herbicide in the United States (Padgett et al., 2000). In 1994 at the time the USEPA Special Review was initiated, atrazine was used on approximately 67%, 65%, and 90% of US corn, sorghum, and sugarcane acreage, respectively. These 1994 percentages of crop treated remain consistent today. 

CUSEPA has utilized the atrazine chronic NOEL of 1.8mg/kg/day for cumulative risk assessment. dUK 2007 draft review submitted to the European Commission. eUSEPA 1995 Registration Eligibility Decision. 

Worldwide there have been a total of 20 commercialized triazine herbicides. Of the 20 triazines, 7 are currently registered for land use within the United States ametryn, atrazine, metribuzin, prometryn, simazine, terbutryn, and prometon. For purposes of this discussion, only dietary estimates for the 5 most widely used domestic triazines are presented since the USEPA revoked cyanazine tolerances in 2004, prometon is not used for food crops and terbutryn has very limited use. Additionally, propazine was used under USEPA Section 18 registrations in the 1990s, and in 2007 was registered for weed control in sorghum (USEPA, 2007). 

Pest Management Regulatory Agency (PMRA) (2003). Re-evaluation of Atrazine, Proposed Acceptability for Continued Registration Document, PACR 2003-13, Ottawa, Canada. 

Several studies using either passive dosimetry or biological monitoring, or both methods, were submitted by the registrant to assess exposure to workers in the US com belt. The details of these studies are found in the USEPA Revised Human Health Risk Assessment (USEPA, 2002) and the USEPA Re-registration Eligibility Document (USEPA, 2003) on atrazine. 

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