Asthma natural history

Schoenwetter WF. 2000. Allergic rhinitis Epidemiology and natural history. Allergy Asthma Proc. 21 1-6. 

Johnstone D A study of the natural history of bronchial asthma in children. Am J Dis Child 1968 115 213-221. 

SzczekUk A, Nizankowska E, Duplaga M. Natural history of aspirin-induced asthma. AIANE Investigators. European Network on Aspirin-Induced Asthma. Eur Respir J 2000 16(3) 432-6. 

Chan-Yeung M, Lam S, Keener S Clinical features and natural history of occupational asthma due to western red cedar (Thujaplicata). Am J Med 1982 72 41141.. (Ill)... 

Gem JE, Busse WW The role of viral infections in the natural history of asthma. J Allergy Clin Immunol 2000 106 201-212. 

CHAN-YEUNG, M. MALO, J.-L. (1993) Table of the major inducers of occupational asthma, in BERNSTEIN, I.L., CHAN-YEUNG, M MALO, J.-L. BERNSTEIN, D.I. (Eds) Asthma in the Workplace, pp. 595-624. New York Marcel Dekker. CHAN-YEUNG, M., LAM, S. KOENER, S. (1982) Clinical features and natural history of occupational asthma due to western red cedar (Thuja plicata). American Journal of Medicine, 72, 411—415. 

In addition to skin eruptions aspirin can cause a syndrome referred to as aspirin exacerbated respiratory disease (AERD) in which the classic triad of asthma, rhinitis, and aspirin sensitivity was first described by Sam ter. It is important to note that AERD has as its precursor an underlying respiratory disease such as asthma that is exacerbated by aspirin but not caused by aspirin. Briefly, the natural history of this disease indicates that the patient first develops an upper respiratory tract inflammation that persists rather than subsides. Sinusitis develops, which progresses to pansinusitis with nasal polyps and asthma noted. At some point the patient takes aspirin or some other COX-1 inhibitor and an AERD reaction occurs. Although this is truly an idiopathic reaction to NSAIDs, adult patients with chronic sinusitis and nasal polyps should be observed carefully for the potential development of AERD. 

Fleischer, D.M., The natural history of peanut and tree nut allergy, Curr. Allergy Asthma Rep., 1, 175-181, 2007. 

Aaronov, D., D. Tasher, A. Levine, et al. 2008. Natural history of food allergy in infants and children in Israel. Arm. Allergy Asthma Immunol. 101(6) 637-640. 

The individual atopic conditions have different natural histories. Although any one may develop for the first time at any age, each tends to have a typical pattern. Individual patients may have only a single manifestation, or multiple manifestations either sequentially or concurrently. Gastrointestinal reactions to foods are most common in the first year and are often transient. Eczema also tends to develop in the first few months of life. Roughly 50% continue to have some disease activity into adult life. Childhood asthma often improves around puberty, but presentation in early adult life is also common. Allergic rhinitis may be associated with any of the previous conditions in childhood, but when occurring alone, has a peak onset between 15 and 25 years. 

The natural history of aspirin-induced asthma, or aspirin triad, begins with ihinorrhea and nasal congestion. This proceeds to rhinitis which becomes perennial and associated with chronic sinusitis and nasal polyps. Asthma develops 1-5 years after the onset of rhinitis. The disease usually appears at an age of 30-34 years and its course is usually more severe and progressive in women who outnumber men. 

Reed CE. The natural history of asthma. J Allergy Chn Immunol 2006 118 543-548. Feldman DM, Baron S, Mueller CA, et al. Initial symptoms, respiratory function and respirator use in New York City firefighters responding to the World Trade Center (WTC) disaster. Chest 2004 125 1256-1264. 

Croner S, Kjelhnan N. Natural history of bronchial asthma in childhood. Allergy 1992 47 150-157. 

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