Ashbya gossypii

Riboflavin (vitamin Eremothecium ashbyii Ashbya gossypii Treatment of vitamin B2 deficiency disease... 

Stahmann, K.-P, Revuelta, J.L., and Seulberger, H., Three biotechnical processes using Ashbya gossypii, Candida famata and Bacillus subtilis compete with chemical riboflavin production, Appl. Microbiol. Biotechnol., 53, 509, 2000. 

A number of fungi have a failure of the normal regulation of riboflavin synthesis and are overproducers of the vitamin. Mutants of Ashbya gossypii may accumulate up to 150 /xmol of riboflavin per gram of protein, compared with a normal content of 0.25 /xmol per gram of protein. They can produce and excrete so much that riboflavin crystallizes in the culture medium. Such fungi are used for the commercial production of riboflavin by fermentation, as an alternative to chemical synthesis. 

Vitamin Bj (riboflavin) Sugars, whey Ashbya gossypii Eremothecium ashbyi... 

Ashbya gossypii Fermentation Process with Plant Oils as Carbon and Energy Source 133... 

Bacillus subtilis and Ashbya gossypii as Preferred Host Strains... 

Eremothecium ashbyi, Ashbya gossypii, yeast Candida famata, and bacteria Clostridium aceto-butylicum and B. subtilis. Out of this, A.gossypii and B. subtilis are mainly used for commercial level production of riboflavin, which took over the established chemical synthesis during the last two decades7 ... 

Jimanez A, Santos MA, Pompejus M, Revuelta JL. Metabolic engineering of the purine pathway for riboflavin production in Ashbya gossypii. Appl Environ Microbiol 2005 71 5743-51. 

Added support for the supposition that the biosynthesis of riboflavin and cyanocobalamin make use of a common precursor comes from the increased synthesis of riboflavin by Ashbya gossypii in cobalt-supplemented media (Hickey, 1954) and from the stimulation of riboflavin formation in a Saccharomyces cerevisiae mutant by purines, glycine, and methionine (Giri and Krishnswamy, 1964). 

B., and Sahm, H. (1996) Correlation of isocitrate lyase activity and riboflavin formation in the riboflavin overproducer Ashbya gossypii. Microbiology, 142, 419-426. 

X et al. (2009) Increased riboflavin production from activated bleaching earth by a mutant strain of Ashbya gossypii. 

Extraction of Ashbya gossypii cell paste with 95% ethanol... 

Besults of the incorporation of radioactive compounds into riboflavin by Ashbya gossypii and Eremolhecnim ashbyii are discussed in relation to... 

Late in the 1960s, concurrently with the development of the riboflavin fermentation process, a synthetic means of producing riboflavin was discovered. This synthetic process dominated the production of riboflavin until 1972 when some major fermentation strain and process improvements were made with the Ashbya gossypii strain. Since then yields have been significantly improved. The fermentation method now accounts for essentially all the riboflavin produced. 

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