Ascaris suum metabolic transitions

Metabolic Transitions and the Role of the Pyruvate Dehydrogenase Complex During Development of Ascaris suum... 

The parasitic nematode, Ascaris suum, undergoes a number of well-characterized metabolic transitions during its development (Table 14.1), but little is known about the regulation of these events (Barrett, 1976 Komuniecki and Komuniecki, 1995). Adults reside in the porcine small intestine and fertilization takes place under low oxygen tensions. The unembryonated egg that leaves the host is metabolically quiescent, has no detectable cytochrome oxidase activity or ubiquinone and appears to be transcriptionally inactive (Cleavinger et al., 1989 Takamiya et al., 1993). Embryonation requires oxygen and after about 48-72 h is accompanied by... 

Table 14.1. Metabolic transitions during the development of Ascaris suum.

Komuniecki, R. and Komuniecki, P.R. (1995) Aerobic-anaerobic transitions in energy metabolism during the development of the parasitic nematode Ascaris suum. In Boothroyd, J.C. and Komuniecki, R. (eds) Molecular Approaches to Parasitolog. Wiley-Liss, New York, pp. 109-121. 

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