As antiviral agents

Thiosemicarba2ones have long been used as antiviral agents, principally against pox vimses of the vaccinia family. One compound of this series, the isatin derivative (6) C HgN OS, has been used prophylacticaHy to prevent outbreaks of smallpox in humans (10) and to inhibit the protein synthesis in poxvims-infected cells. The molecular mechanics relating to this property are still not known (11), though the binding of a metal ion may be a key factor... 

Patick AK, Potts KE (1998) Protease inhibitors as antiviral agents. Clin Microbiol Rev 4 614—627... 

Alymova IV, Taylor G, and Portner A (2005). Neuraminidase inhibitors as antiviral agents. Current... 

A -(4-Chlorobenzyl)-7-substituted-4-oxo-477-pyrimido[l,2- ]pyridazine-3-carboxamides have been claimed as compounds to treat atherosclerosis and restenosis <2004W02004/019933> and as antiviral agents, particularly against herpes viruses <2002W02002/004444>. The 7-substituted-2-phenyl-pyrimido[l,2- ]pyridazin-5-ium-3-olates 99... 

Alvarez-Salas, L.M., Benitez-Hess, M.L., and DiPaolo, J.A. 2003. Advances in the development of ribozymes and antisense oligodeoxynucleotides as antiviral agents for human papillomaviruses. Antiviral Therapy 8(4), 265-278. 

Access to modified nucleosides. Base-modified nucleosides and nucleotides are very important for their biological properties. They can be found as antiviral agents (HBH, VZV, AIDS),93 95 in the study of DNA degradation,96,97 as fluorescent agents and as chemical probes of DNA structure.98 101 The access to nucleosides can be achieved by different methods ... 

Durantel D, Alotte C, Zonlim F. (2007) Glncosidase inhibitors as antiviral agents for hepatitis B and C. Curr Opin Invest Drugs 8 125-129. 

Martin JC (1989) Nucleotide Analogues as Antiviral Agents, ACS Symp. Ser. 401, Washington... 

Although there has heen a great deal of research concerning how platinum(II) complexes hind to biological molecules and the hkely mechanism of antitumor activity of these platinum-containing species, far less attention has heen paid to the properties of other metal complexes in this arena. Recent attention has fallen on cohalt(II)-Schiff hase complexes, as several have heen discovered to have promise as antiviral agents. A review of recent work has appeared elsewhere [64], so the topic will not he covered here however, in addition to focusing on recent developments, emphasis is placed on the introduction of the new head unit, 3,6-diformylpyridazine (13), into Schiff-hase macrocyclic electrochemistry. 

It is indicated in hairy cell leukemia, AIDS related Kaposi s sarcoma (the detailed pharmacology and its use as antiviral agent is discussed in chapter Antiviral agents ). 

Nucleotide Analogs as Antiviral Agents Martin, J. C.. Ed. ACS Symposium Series 401, American Chemical Society, Washington, DC, 1989. 

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