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Goldring, M. B. (1997) The musculoskeletal system articular cartilage. In Primer on the Rheumatic Diseases (J. H. Klippel, ed.), The Arthritis Foundation, Atlanta, pp. 14-18. 

This work was supported in part by the Arthritis Foundation and by NCI Grant CA-13148 (NMR Facility). The authors thank Drs. John Baker and Ted Sakai for their critical reading of the manuscript and for their comments, and Dr. Derek Horton for his editorial corrections and comments on this manuscript. 

This work was supported in part by Grant AM 10531 from The National Institute of Arthritis, Metabolic and Digestive Diseases, National Institutes of Health, and grants from the National Foundation-March of Dimes and from the Arthritis Foundation, Michigan Chapter. 

The Immunology Branch, Division of Host Factors, Center for Infectious Diseases, Centers for Disease Control, Public Health Service, U.S. Department of Health and Human Services, Atlanta, Georgia tDepartments of Medicine and Microbiology, Emory University School of Medicine, Atlanta, Georgia and The Arthritis Foundation, Atlanta, Georgia... 

Public Health Service, U.S. Department of Health and Human Services, Atlanta, Georgia 30333 The Arthritis Foundation, Atlanta, Georgia 30309... 

This work was supported by grants from the National Insdtutesof Health (ROl AR 39020), the New Jersey Chapter of the Arthritis Foundation, and the Foundation of the University of Medicine and Dentistry of Newjersey. 

From Klippel JH, Wayand CM, Wortmann R, et al., eds. Primer on the Rheumatic Diseases. 12th Ed. Atlanta Arthritis Foundation, 2001 with permission. 

These are synthetic versions of compounds the body makes to stimulate the growth of cartilage. The theory is that these compounds rebuild cartilage and reduce the symptoms of arthritis. It is an acceptable treatment in veterinary medicine, but the Arthritis Foundation and the American College of Rheumatology have not recommended it for humans. The Food and Drug Administration has not approved it to treat arthritis. At this time, they are sold as nutritional supplements, and therefore do not need evidence that they are safe and effective. 

Research supported in part by PHS grants GM17702, AM13622, HD10847, The Kroc Foundation and the Clayton Foundation. Dr. Gruber is a Fellow of the Arthritis Foundation. 

ACKNOWLEDGEMENT The author s studies reported here were supported in part by Grant AM- 28554 from the National Institutes of Health and a grant from the Illinois Chapter of the Arthritis Foundation. 

This work was supported by the Howard Hughes Medical Institute and by a Robert A. Welch Foundation grant (Q-533) to C T C J B was supported by a Arthritis Foundation Fellowship ... 

Dr. Faller is supported by an Arthritis Foundation Postdoctoral Fellowship. 

Supported by USPHS grant AM19674 and 5 MOl RR00042 and a grant from Michigan Heart Association and Warner/Lambert-Parke/Davis. Dr. John is supported by an Arthritis Foundation Postdoctoral Fellowship. 

This work was supported by grants from the U.S. Public Health Service (CA-15802) and the National Science Foundation (GB-40814). J.L.S. is a fellow of the Arthritis Foundation. 

Schumacher HR. KlippelJH Koopman WJ. Primer on tin-Rheumatic Diseases, Wlh ed. Atlanta Arthritis Foundation, 1993. 

Arthritis is a dreaded and feared crippling disease. The Arthritis Foundation estimates that more than 13 million Americans are afflicted by some form of this condition, and that a quarter of a million more become victims of this disease every year. The human suffering from arthritis is awesome and the cost in dollars is almost impossible to comprehend. Figures show that arthritis sufferers lose an estimated 115 million days a year from work, which is equivalent to 470,000 persons on sick leave for an entire year. This is more days lost from work than is caused by any other malady except nervous and mental diseases. 

This work was supported by the National Science Foundation (CAREER Award to J.P.F. 0448684), Arthritis Foundation (Arthritis Investigator Award to J.P.F.), and the State of Maryland, Maryland Stem Cell Research Fund. 

Acknowledgements We acknowledge Gaiuav Arya (Department of Chemistry and Courant Institute of Mathematical Sciences, New York University) for valuable discussions. We also acknowledge financial support from the Whitaker Foundation and an arthritis investigator award from the Arthritis Foundation and Johns Hopkins University. 

Acknowledgements AJG gratefully acknowledges support from the National Science Foundation, National Institutes of Health, Arthritis Foundation, Whitaker Foundation, and the Georgia Tech/Emory NSF ERG on Engineering Living Tissues. 

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