Musculoskeletal system articular cartilage

Goldring, M. B. (1997) The musculoskeletal system articular cartilage. In Primer on the Rheumatic Diseases (J. H. Klippel, ed.), The Arthritis Foundation, Atlanta, pp. 14-18. 

Several agents and therapeutic principles addressing musculoskeletal disorders, applied either systemically or intraarticularly, have been discussed to potentially impair the integrity of articular cartilage (Raynauld et al. 2003 Adams et al. 2000 Theiler et al. 1994). Therefore, a reliable cellular assay is of interest to detect chondrodeleterious properties of a test drug in its early developmental stages. 

This book is aimed at teaching senior engineering students or orthopaedic residents the fundamental principles of biomechanics of the musculoskeletal system. The book contains several chapters on the mechanics of joints, and the properties and functions of joint tissues. The chapter devoted to articular cartilage and the meniscus includes a review of collagen-proteoglycan interactions, and how these directly affect the mechanical behavior of the tissue. The biphasic and the triphasic theories for the viscoelastic properties are also discussed. 

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