Arsenical dust

Arsenic causes both skin and lung cancer. Skin cancer was observed over 100 years ago in patients treated with arsenical compounds, and lung cancer was seen in smelter workers who chronically inhaled arsenic dust. Although arsenic is an established human carcinogen, it has been difficult to confirm and study in animal models. Arsenic readily crosses the placenta, but there appears to be increased methylation of arsenic to its organic form, which reduces its toxicity to the fetus. 

Determination of Arsenic in Gases.—To estimate the number of particles of arsenical dust in a sample of air, counts of the number of particles in a dust sample are made before and after heating at 250° C. at this temperature arsenious oxide is removed but other constituents are unaltered.2... 

N., Freeman, C., Gahchet, L., and Cogliano, V., on behalf of the WHO International Agency for Research on Cancer Monogr h Working Group (2009). A review of human carcinogens— part C metals, arsenic, dusts, and fibres. Lancet Oncol 10, 453 54. 

Dahmann (Germany) 2008 Uranium mining industry Dust, crystalline silica, arsenic Dust measurements (mg/m )... 

Calcium Arsenate Dust mask goggles or face shield protective gloves. Move to fresh air. Flush with water, wash with soap and water. Flush with water for at least 15 minutes. 

CAS/DOT IDENTIFICATION Organic arsenic compounds have variable CAS s. The CAS for arsenic is 7440-38-2. The DOT identification numbers for metallic arsenic and arsenic dust are 1558 and 1562, respectively. 

B. Inorganic arsenic dusts (such as arsenic trioxide) may exert irritant effects on the skin and mucous membranes. Contact dermatitis has also been reported. Although the skin is a minor route of absorption for most arsenic compounds, systemic toxicity has resulted from industrial accidents involving percutaneous exposure to highly concentrated liquid formulations. 

Arsenical Dust. Smelter dust which contains large proportions of arsenic. These dusts are hazardous due to their toxic characteristics. ICAO A2... 

Second phase The worker complains of conjunctivitis, a catarrhal state of the mucous membranes of the nose, larynx, and respiratory passage. Coryza, hoarseness, and mild tracheobronchitis may occur. Perforation of the nasal septum is common, and is probably the most typical lesion of the upper respiratory tract in occupational exposure to arsenical dust. Skin lesions, eczematoid and allergic in type, are common. 

Taljaard JJF, Shanley BC, Deppe WM, Joubert SM (1972) Porphyrin metabolism in experimental hepatic siderosis in the rat. II. Combined effect of iron overload and hexachlorobenzene. Br J Haematol 23 513-517 Telolahy P, Javelaud B, Cluet J, de Ceaurriz J, Boudene C (1993) Urinary excretion of porphyrins by smelter workers chronically exposed to arsenic dust. Toxicol Lett 66 89-95... 

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