Arginine deiminases

Arginine deiminase (ADI) pathway (Mercenier et al. 1980) arginine —> citrulline ornithine + carbamoyl phosphate... 

Mercenier A, J-P Simon, CV Wauven, D Haasm, V Stalon (1980) Regulation of enzyme synthesis in the arginine deiminase pathway of Pseudomonas aeruginosa. J Bacteriol 144 159-163. 

A representative example of a biocatalytic membrane electrode is an electrode for L-arginine The bacterium streptococcus faecium is immobilized on the gas permeable membrane of an ammonia electrode. Arginine deiminase in the bacterium catalyzes the following reaction... 

Hibbs, J. B.,Jr., Taintor, R. R., Vavrin, Z Macrophage cytotoxicity role for L-arginine deiminase and imino nitrogen oxidation to nitrite, Science 235 (1987), p. 473-476... 

Kearney, P.L., Bhatia, M., Jones, N.G., Yuan, L., Glascock, M.C., Catchings, K.L., Yamada, M. and Thompson, P.R. (2005) Kinetic characterization of protein arginine deiminase 4 a transcriptional corepressor implicated in the onset and progression of rheumatoid arthritis. Biochemistry, 44, 10570-10582. 

Thompson, P.R. and Fast, W. (2006) Histone citrullination by protein arginine deiminase is arginine methylation a green light or a roadblock ACS Chemical Biology, 1, 433-441. 

Tarcsa, E., Marekov, L. N., Andreoli, J., Idler, W. W., Candi, E., Chung, S. I., and Steinert, P. M. (1997). The fate of trichohyalin. Sequential post-translational modifications by peptidyl-arginine deiminase and transglutaminases. /. Biol. Chem. 272, 27893-27901. 

Arginine deiminases catalyze the conversion of arginine residues to citrulline residues in proteins. Deregulation of protein arginine deiminase 4 (PAD4) is... 

Scheme 13 Haloacetamide arginine deiminase probes and modes of labeling...

Jones JE, Causey CP, Rnuckley B et al (2009) Protein arginine deiminase 4 (PAD4) current understanding and future therapeutic potential. Curr Opin Drug Discov Devel 12 616-627... 

Luo Y, Arita K, Bhatia M et al (2006) Inhibitors and inactivators of protein arginine deiminase 4 functional and structural characterization. Biochemistry 45 11727-11736... 

Luo Y, Knuckley B, Lee YH et al (2006) A fluoroacetamidine-based inactivator of protein arginine deiminase 4 design, synthesis, and in vitro and in vivo evaluation. J Am Chem Soc 128 1092-1093... 

Slack JL, Causey CP, Luo Y et al (2011) Development and use of clickable activity based protein profiling agents for protein arginine deiminase 4. ACS Chem Biol 6 466-476... 

Inclusion of arginine (16 mM) and 0.4 mg% phenol red indicates the presence of arginine deiminase by formation of alkali (purple colouration). 

Luo Y, Knuckley B, Bhatia M, Pellechia PJ, Thompson PR. Activity-based protein profiling reagents for protein arginine deiminase 4 (PAD4) synthesis and in vitro evaluation of a fluorescently labeled probe. J. Am. Chem. Soc. 2006 128 14468-14469. 

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