Applications sustained release devices

D B Mirth, The uk of controlled and sustained release devices in dentistry A review of applications for the control of dental caries , Phartrutcol Ther Dent, 1980 5 59-67. 

It is clear that the involvement of implants by infections is a major problem in the clinical application of these devices and prostheses. While numerous clinical methods and techniques will be used to reduce the morbidity and mortality of these infections, there exists an opportunity for the pol3nner scientist to develop infection resistant materials or sustained release devices which can be used to combat these infections (31). 

As with PLA or PLG carriers, the application of either polyanhydride or polyorthoester polymers for 5-FU sustained release in glaucoma treatment or PVR has been investigated. Using compression techniques, polyanhydride devices constructed from combinations of(p-carboxyphenoxy)alkanes with sebacic acid have been produced. Disk or T-shaped polyanhydride devices containing between 10 and 20%i 5-FU prolonged lOP reduction and bleb survival in filtration models or... 

Debenedetti PG, Tom JW, Yeo SD, Lim GB. Application of supercritical fluids for the production of sustained release delivery devices. J Controlled Release 1993 24 27 4. 

The development of polymeric drug delivery devices for sustained ophthalmic CsA release is an active area of research for uveitis, vitreous inflammation, dry eye, and prevention of cornea transplant rejection. The use of these specialized CsA-delivering ophthalmic systems (e.g., implants nanoparticle and microsphere injections) cannot be completely reviewed in this chapter and readers are referred to an alternative text. A sample of applicable polymers for delivery of CsA for uveitis and vitreous inflammation is offered in the accompanying table (Table 15.4). The treatment of posterior uveitis and vitreous inflammation usually involves chronic therapy (often years) of topical agents and frequent intravitreal injections for disease control. These therapies are often impractical and subject to medical non-adherence [33]. Polymeric implants or injectable polymer sustained release systems can potentially improve patient outcomes through optimized intraocular drug concentrations. 

KRs, due to these features and their ability to support also the sustained release of therapeutic agents, have attracted both academic and industrial interest. Keratin-based biomaterials, indeed, could find applications in several fields, such as tissue engineering, regenerative medicine, drug delivery, trauma, and medical devices. 

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